Naslov
Do lampreys have lymphocytes? The Spi evidence.
(Do lampreys have lymphocytes? The Spi evidence)

Autori
Shintani, S. ; Terzić, Janoš ; Sato, Akie ; Saraga-Babić, Mirna ; O'hUigin, Colm ; Tichy, Herbert ; Klein, Jan

Izvornik
Proceedings of the National Academy of Sciences of the United States of America (0027-8424) 97 (2000), 13; 7417-7422

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
imune response; lymphocyte development

Sažetak
It is generally accepted that living jawless vertebrates (lampreys and hagfishes) lack the capability of mounting an adaptive immune response. At the same time, however, there are reports describing histological evidence for the presence in agnathan tissues of lymphocytes, the key players in adaptive immunity. The question therefore arises whether the cells identified morphologically as lymphocytes are true lymphocytes in terms of their genetic developmental program. In this study, evidence is provided that the lampreys express a member of the purine box 1 (PU.1)/spleen focus-forming virus integration B (Spi-B) gene family known to be critically and specifically involved in the differentiation of lymphocytes in jawed vertebrates. The lamprey gene is expressed in the lymphocyte-like cells of the digestive tract and inexplicably also in the ovary.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA