Histologic detection of additional nodal metastases in breast carcinoma with positive sentinel node

Mustać, Elvira; Matušan-Ilijaš, Koviljka; Marijić, Blažen; Smokvina, Aleksandar; Jonjić, Nives

Pregled bibliografske jedinice broj: 494025

Histologic detection of additional nodal metastases in breast carcinoma with positive sentinel node

Mustać, Elvira; Matušan-Ilijaš, Koviljka; Marijić, Blažen; Smokvina, Aleksandar; Jonjić, Nives

Histologic detection of additional nodal metastases in breast carcinoma with positive sentinel node // Abstracts of the 22nd European Congress of Pathology ; u: Virchows Archive 455 (2009) (S1) S1–S482 ; Poster session 2: Breast pathology ; P2.6
Firenca, Italija, 2009. str. 180-180 (poster, međunarodna recenzija, sažetak, znanstveni)

CROSBI ID: 494025 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Histologic detection of additional nodal metastases in breast carcinoma with positive sentinel node

Autori
Mustać, Elvira ; Matušan-Ilijaš, Koviljka ; Marijić, Blažen ; Smokvina, Aleksandar ; Jonjić, Nives

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 22nd European Congress of Pathology ; u: Virchows Archive 455 (2009) (S1) S1–S482 ; Poster session 2: Breast pathology ; P2.6 / - , 2009, 180-180

Skup
European Congress of Pathology (22 ; 2009)

Mjesto i datum
Firenca, Italija, 04.09.2009. - 09.09.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
additional lymph node metastases; breast carcinoma; Sentinel lymph node

Sažetak
Axillary lymph node dissection (ALND) is an important procedure in the staging of breast cancer patients. A lymph node defined as sentinel lymph node (SLN) would be the first to receive tumoral drainage. The aim of this study was to estimate the likelihood of additional disease in the axilla after SLN mapping. A total of 259 breast carcinomas and SLN biopsies followed by ALND were examined. The patient median age was 59 years, approximately 75% of them postmenopausal. Tumor size was 1.4±0.8 cm (almost 80% in pT1). SLNs were positive in 59 of 259 (22.8%) carcinomas, 30 (11.6%) with micrometastases (<2.0 mm) and 29 (11.2%) with metastases. Tumor size (p=0.004) and presence of lymphovascular invasion (LVI) (p=0.034) were found to be significant predictors of pathologically positive SLN. Positive non-SLNs were present mostly in patients with metastasis >2 mm in SLN (p=0.003), in carcinoma with higher nuclear grade (p=0.044), decreased ER (p=0.042), and PR (p=0.042). Finally, lymph node status (pN) following SLN and ALND was found to be significantly associated with tumor size (p=0.006), LVI (p=0.037), PR (p=0.023) and Her-2 status (p<0.001). These results point to detailed analysis of primary tumor and SLN that may increase the precision of patient selection for further axillary surgery or radiotherapy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
DOI 10.1007/s00428-009-0805-z

POVEZANOST RADA

Projekti:
062-0620095-0077 - Molekularni mehanizmi tumorske progresije i metastaziranja raka dojke i prostate (Mustać, Elvira, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Blažen Marijić (autor)