Naslov
Syntheis and antitumor activity of new cyano and amidio-substituted 2-phenylbenzothiazoles

Autori
Racane, Livio ; Kitson ; P. Richard ; Tralić-Kulenocvić, Vesna ; Karminski-Zamola, Grace

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Drugs of the Future : abstracts / - Kopenhagen, 2004, 390-390

Skup
XVIII EFMC International Symposium on Medicinal Chemistry

Mjesto i datum
Kopenhagen, Danska; Malmö, Švedska, 15.08.2004. - 19.08.2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
syntheis ; antitumor activity of new cyano and amidio-substituted 2-phenylbenzothiazoles

Sažetak
A number of sustituted benzothiazoles exhibit useful pharmacological activities. Continuing our studies on the synthesis of some effective compounds against cancer, we prepared some new cyano and amidino-substituted benzothiazoles. Starting with o-aminothiophenole or 2-mercapto-3-amino-benzonitrile and benzaldehyde or p-cyanobenzaldehyde we obtained corresponding mono or dinitriles by condensation reaction.Amidines as hydrochloric salts were prepared by Pinner reaction of appropriate nitriles. Antitumor evaluation were carried out human cell lines: DU-145 (prostate cancer), HT-1080 (fibro sarcoma), MDA-MB-231 (breast carcinoma)and A549-met (lung carc inoma). All compounds shawed certain antiproliferative effect in vitro on these cell lines.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija

POVEZANOST RADA