Naslov
Association analyses of 249, 796 individuals reveal 18 new loci associated with body mass index

Autori
Speliotes, Elizabeth K. ; ... ; ; Kolčić, Ivana ; ... ; Mulić, Rosanda ; ... ; Polašek, Ozren ; ... ; Zgaga, Lina ; ... ; Rudan, Igor ; Loos, R.J.F.

Izvornik
Nature genetics (1061-4036) 42 (2010), 11; 937-948

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
body mass index; genome-wide association; meta-analysis

Sažetak
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ∼ 2.8 million SNPs in up to 123, 865 individuals with targeted follow up of 42 SNPs in up to 125, 931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10⁻⁸), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

Napomena
The GIANT Consortium (373 koautora).

POVEZANOST RADA