Naslov
Vascular cognitive impairment in stroke-free patients with carotid stenosis or occlusion

Autori
Martinić-Popović, Irena ; Lovrenčić-Huzjan, Arijana ; Šodec-Šimičević, Darja ; Strineka, Maja ; Demarin, Vida

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of The 50th International Neuropsychiatric Pula Congress ; u: Acta Clinica Croatica (2010) (S) / - , 2010, 102-102

Skup
International Neuropsychiatric Pula Congress (50 ; 2010)

Mjesto i datum
Pula, Hrvatska, 16.06.2010. - 19.06.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
vascular cognitive impairment; cognitive decline; carotid artery disease; atherosclerosis

Sažetak
Vascular cognitive impairment (VCI) is nowadays deemed the most common form of cognitive decline that can potentially be prevented or ameliorated. Besides well known vascular risk factors that have a key role in the development of VCI, concomitant advanced stenosis or occlusion of the internal carotid artery (ICA s/o) could further increase the risk of cognitive decline due to chronic hypoperfusion. We therefore evaluated cognitive functions in patients with vascular risk factors with and without advanced carotid disease. Cognitive status of 42 patients with vascular risk factors, diagnosed with mild cognitive impairment (MCI) and with advanced ICAs/o (PG) was compared with age and gender matched control group of 42 MCI patients with vascular risk but without ICAs/o (CG). Cognitive testing was performed using MMSE and Montreal Cognitive Assessment (MoCA). Cognitive performance on both tests and on cognitive domains covered by MoCA was correlated with vascular risk profile. Compared to MCI patients without concomitant advanced ICA s/o, MCI patients with ICA s/o scored signifi cantly worse on MoCA (p=0, 049) and on the short-term memory domain MoCA subtest (p=0, 026). MMSE cognitive scores did not diff er signifi cantly between groups. Analysis of cognitive domains covered by MoCA in subgroups of participants with diff erent vascular risk factors showed signifi cant association of impaired attention with hypertension, diabetes, hyperlipidaemia, smoking and with multiple risk factors (>2). Diabetes was also signifi cantly associated with the impaired language domain (p< 0, 05). Patients with vascular risk factors and concomitant advanced carotid disease seem to be at increased risk of developing cognitive decline. Th e pattern of cognitive impairment could be easily revealed when MoCA subtests scores are analysed.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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