Pregled bibliografske jedinice broj: 490066
Protein instability and stability, a formulation challenge
Protein instability and stability, a formulation challenge // 1st World Conference on Physico-Chemical Methods in Drug. Discovery and Development: Knjiga sažetaka = Book of abstracts
Lahti, 2009. str. 33-33 (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 490066 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Protein instability and stability, a formulation challenge
Autori
Cindrić, Mario ; Pavišić, Renata
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
1st World Conference on Physico-Chemical Methods in Drug. Discovery and Development: Knjiga sažetaka = Book of abstracts
/ - Lahti, 2009, 33-33
Skup
1st World Conference on Physico-Chemical Methods in Drug. Discovery and Development
Mjesto i datum
Rovinj, Hrvatska, 27.09.2009. - 01.10.2009
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Protein; Instability; Stability; Pharmaceutical formulation
Sažetak
Development of stable protein or peptide formulation is one of the critical steps in pharmaceutical protein formulation development, towards to the final therapeutic product. A major challenge is to maintain the integrity of a protein drug during pharmaceutical processing, storage, handling and administration, knowing that proteins typically raise more stability issues than “small molecules” as a result of macromolecular instability and complexity (numerous reactive chemical centers and degradable elements). Stability issues start with preservation of delicate 3-D structure stabilized by noncovalent interactions such as hydrogen bonding, ionic interactions, Van der Waals’ forces and hydrophobic packing and end with protection of linear amino acid sequence and potential post-translational modifications. By determining stabilizing effect of a given stabilizer under the specific physico-chemical conditions, selection and/or comparison of the stabilizers used followed by statistical evaluation bring out general rules that can be applied to prevent unwanted protein/peptide degradation processes. As the science of formulating protein drug today is very much an interdisciplinary problem, together with new advances in the fields such as medicinal research, analytical and pharmaceutical development, manufacturing (process chemistry and engineering), as well as quality and regulatory requirements, new topics in the area of protein formulation emerge.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija, Farmacija
