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Pregled bibliografske jedinice broj: 489832

Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles

Hranjec, Marijana; Starčević, Kristina; Kraljević Pavelić, Sandra; Lučin, Pero; Pavelić, Krešimir; Karminski-Zamola, Grace
Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles // European journal of medicinal chemistry, 46 (2011), 6; 2274-2279 doi:10.1016/j.ejmech.2011.03.008 (međunarodna recenzija, članak, znanstveni)

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Naslov
Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles

Autori
Hranjec, Marijana ; Starčević, Kristina ; Kraljević Pavelić, Sandra ; Lučin, Pero ; Pavelić, Krešimir ; Karminski-Zamola, Grace

Izvornik
European journal of medicinal chemistry (0223-5234) 46 (2011), 6; 2274-2279

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
benzimidazoles ; Schiff bases ; antiproliferaive evaluation ; UV/Vis and fluorescence spectroscopy

Sažetak
A series of novel benzimidazole substituted Schiff bases were synthesized by reaction of aromatic aldehydes with corresponding 2-aminobenzimidazoles. Their structure has been studied by 1H and 13C NMR, IR and UV/Vis spectroscopy. Majority of prepared Schiff bases were tested on their antiproliferative activity in vitro and exerted non-specific antiproliferative activity on the tested cell lines at the highest tested concentration. Compounds 18 and 19 exerted the strongest non-specific antiproliferative effect on all cell lines and a concentration-dependent effect on HeLa and MCF-7 cell lines at micromolar concentrations but simultaneously being highly cytotoxic on human fibroblasts as well.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
MZOS-062-0620238-0223 - Sortiranje MHC-I molekula na staničnoj membrani i endocitoznim odjeljcima (Lučin, Pero, MZOS ) ( CroRIS)
MZOS-125-0982464-1356 - Novi heterocikli kao antitumorski i antivirusni (pametni) lijekovi (Hranjec, Marijana, MZOS ) ( CroRIS)
MZOS-335-0000000-3532 - Uloga IGF2 i signalni putovi nizvodno u karcinomima pluća čovjeka (Peter-Katalinić, Jasna, MZOS ) ( CroRIS)
098-0982464-2393 - Molekularna obilježja miofibroblasta Dupuytrenove bolesti

Ustanove:
Medicinski fakultet, Rijeka,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Sveučilište u Rijeci - Odjel za biotehnologiju

Profili:

Avatar Url Krešimir Pavelić (autor)

Avatar Url Sandra Kraljević Pavelić (autor)

Avatar Url Grace Karminski-Zamola (autor)

Avatar Url Pero Lučin (autor)

Avatar Url Kristina Starčević (autor)

Avatar Url Marijana Hranjec (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com dx.doi.org

Citiraj ovu publikaciju:

Hranjec, Marijana; Starčević, Kristina; Kraljević Pavelić, Sandra; Lučin, Pero; Pavelić, Krešimir; Karminski-Zamola, Grace
Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles // European journal of medicinal chemistry, 46 (2011), 6; 2274-2279 doi:10.1016/j.ejmech.2011.03.008 (međunarodna recenzija, članak, znanstveni)
Hranjec, M., Starčević, K., Kraljević Pavelić, S., Lučin, P., Pavelić, K. & Karminski-Zamola, G. (2011) Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles. European journal of medicinal chemistry, 46 (6), 2274-2279 doi:10.1016/j.ejmech.2011.03.008.
@article{article, author = {Hranjec, Marijana and Star\v{c}evi\'{c}, Kristina and Kraljevi\'{c} Paveli\'{c}, Sandra and Lu\v{c}in, Pero and Paveli\'{c}, Kre\v{s}imir and Karminski-Zamola, Grace}, year = {2011}, pages = {2274-2279}, DOI = {10.1016/j.ejmech.2011.03.008}, keywords = {benzimidazoles, Schiff bases, antiproliferaive evaluation, UV/Vis and fluorescence spectroscopy}, journal = {European journal of medicinal chemistry}, doi = {10.1016/j.ejmech.2011.03.008}, volume = {46}, number = {6}, issn = {0223-5234}, title = {Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles}, keyword = {benzimidazoles, Schiff bases, antiproliferaive evaluation, UV/Vis and fluorescence spectroscopy} }
@article{article, author = {Hranjec, Marijana and Star\v{c}evi\'{c}, Kristina and Kraljevi\'{c} Paveli\'{c}, Sandra and Lu\v{c}in, Pero and Paveli\'{c}, Kre\v{s}imir and Karminski-Zamola, Grace}, year = {2011}, pages = {2274-2279}, DOI = {10.1016/j.ejmech.2011.03.008}, keywords = {benzimidazoles, Schiff bases, antiproliferaive evaluation, UV/Vis and fluorescence spectroscopy}, journal = {European journal of medicinal chemistry}, doi = {10.1016/j.ejmech.2011.03.008}, volume = {46}, number = {6}, issn = {0223-5234}, title = {Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles}, keyword = {benzimidazoles, Schiff bases, antiproliferaive evaluation, UV/Vis and fluorescence spectroscopy} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

Uključenost u ostale bibliografske baze podataka::


  • CA Search (Chemical Abstracts)

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