Naslov
Cerebral autoregulation is exhausted in patients with Type 2 diabetes mellitus

Autori
Vuletic, Vlatka ; Cengic, L ; Dikanovic, Marinko ; Bitunjac, Milan ; Marcikic, Marcel ; Kadojic, D

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
International Journal of stroke / - , 2010

Skup
World Stroke Congress

Mjesto i datum
Seoul, Republika Koreja, 13.10.2010. - 16.10.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cerebral autoregulation; cerebral blood flow; type 2 diabetes mellitus; diabetic microangiopathy

Sažetak
The aim of our study was to assess cerebral autoregulation in type 2 diabetes mellitus (DM2). Cerebral autoregulation is the ability to maintain constant cerebral blood flow (CBF) despite changes in the cerebral perfusion pressure and could be evaluated by cerebral vasoreactivity (CVR), a hemodynamic parameter representing the increase in CBF velocity in response to a vasodilatory stimulus, like hypercapnia. Impaired cerebrovascular reactivity is an indicator of the increased risk of stroke. For the evaluation CVR we used breath holding index (BHI) and transcranial Doppler ultrasound (TCD) in 50 patients with DM2 and 50 sex- and age-matched healthy controls. We found statistically significant difference in BHI between patients with DM2 (BHI = 0.69 ! 0.31) and age- and sex- matched healthy controls (BHI = 1.33 ! 0.28, P < 0.05). Our study has shown that cerebral autoregulation is exhausted in patients with DM2. The TCD is the most accurate method in evaluation and monitoring of cerebral haemodynamic changes in diabetic microangiopathy, especially silent ones, and has to be performed periodically on a routine basis in diabetic patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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