Naslov
Intronic polymorphisms of tryptophan hydroxylase and serotonin transporter genes in suicide victims

Autori
Jernej, Branimir ; Štefulj, Jasminka ; Furač, Ivana ; Hranilović, Dubravka ; Bordukalo, Tatjana ; Bokulić, Zvonimir ; Čičin-Šain, Lipa ; Kubat, Milovan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Society for Neuroscience Abstracts / Society for Neuroscience - Washington (MD) : Society for Neuroscience, 2000

Skup
30th Annual Meeting Society for Neuroscience

Mjesto i datum
New Orleans (LA), Sjedinjene Američke Države, 04.11.2000. - 09.11.2000

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
tryptophan hydroxylase; serotonin transporter; gene polyporphism; suicidality

Sažetak
Tryptophan hydroxylase (TPH), as a rate-limiting enzyme of serotonin (5HT) synthesis, and 5HT transporter (5HTt), as a terminator of 5HT synaptic action, represent important regulators of serotonergic neurotransmission. Variants of both protein genes have been associated with sucidal attempts, aggresion and psychiatric illness. In order to further explore the involvement of TPH and 5HTt genes in suicidality, we studied TPH A218C polymorphism in intron 7, and 5HTt VNTR polymorphism in intron 2, in samples of 86 individuals with completed suicide and 91 contols without personal and family history of psychiatric disorders and suicidal behaviour. Both groups belonged to Croatian ethnical population. DNA was obtained from blood samples and genotyped after PCR amplification with specific primers. No significant differences were observed in distribution of 5HTt genotypes or alleles between controls and suicide victims. On the other hand, a significant difference appeared in TPH genotypic distibution between the mentioned groups (c2=7.48, df=2, p<0.05), owing to the higher frequency of CC genotype in suicide victims (odds ratio 2.26). Our results indicate possible involvement of TPH gene (or a gene nearby) in suicidal behaviour and encourage further studies on 5HT synaptic elements in suicide.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA