Naslov
Cell Oxidative Stress: Risk of Metal Nanoparticles

Autori
Poljak-Blaži, Marija ; Jaganjac, Morana ; Žarković, Neven

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, stručni

Knjiga
Handbook of Nanophysics Nanomedicine and Nanorobotics

Urednik/ci
Klaus D. Sattler

Izdavač
CRC Press ; Taylor & Francis

Grad
London : New York (NY)

Godina
2010

Raspon stranica
16-1

ISBN
978-1-4200-7546-5

Ključne riječi
nanoparticles, oxidative stress, nanotoxicology

Sažetak
Metal nanoparticles are highly oxidizable ; therefore, their stabilization by suitable passive surface layer is normally necessary. One of the major mechanisms behind metal toxicity has been attributed to oxidative stress. A growing amount of data provide evidence that metals are capable of interacting with nuclear proteins and DNA causing oxidative deterioration of biological macromolecules. The resulting oxidative stress may also affect levels and functions of numerous redox-sensitive receptors and genes (e.g. growth factor receptors and transcription factors) and/or to induce the cell death causing apoptosis (programmed cell death). Nanoparticles are widely used in consumer products and can reach the body through inhalation, ingestion, skin contact and injection. When nanoparticles are deposited in organs they can modify the physiochemical properties of living matter at the nanolevel thus causing adverse biological reactions. On the other hand, nanoparticles are also used in biomedicine for development of potential new drugs and in diagnostics. Therefore, the biomedical aspects of nanosciences should be studied together with research on toxicological and environmental side effects of nanoparticles.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA