Human Plasma Glycome in Attention-Deficit Hyperactivity Disorder and Autism Spectrum Disorders

Pivac, Nela; Knežević, Ana; Gornik, Olga; Pučić, Maja; Igl, Wilmar; Peeters, Hilde; Crepel, An; Steyaert, Jean; Novokmet, Mislav; Redžić, Irma; Nikolac, Matea; Novković Hercigonja, Vesna; Dodig Ćurković, Katarina; Ćurković, Mario; Nedić, Gordana; Muck-Šeler, Dorotea; Borovečki, Fran; Rudan, Igor; Lauc, Gordan

doi:10.1074/mcp.M110.004200

Pregled bibliografske jedinice broj: 488243

Human Plasma Glycome in Attention-Deficit Hyperactivity Disorder and Autism Spectrum Disorders

Pivac, Nela; Knežević, Ana; Gornik, Olga; Pučić, Maja; Igl, Wilmar; Peeters, Hilde; Crepel, An; Steyaert, Jean; Novokmet, Mislav; Redžić, Irma et al.

Human Plasma Glycome in Attention-Deficit Hyperactivity Disorder and Autism Spectrum Disorders // Molecular & cellular proteomics, 10 (2011), 1; M110.004200, 7 doi:10.1074/mcp.M110.004200 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 488243 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Human Plasma Glycome in Attention-Deficit Hyperactivity Disorder and Autism Spectrum Disorders

Autori
Pivac, Nela ; Knežević, Ana ; Gornik, Olga ; Pučić, Maja ; Igl, Wilmar ; Peeters, Hilde ; Crepel, An ; Steyaert, Jean ; Novokmet, Mislav ; Redžić, Irma ; Nikolac, Matea ; Novković Hercigonja, Vesna ; Dodig Ćurković, Katarina ; Ćurković, Mario ; Nedić, Gordana ; Muck-Šeler, Dorotea ; Borovečki, Fran ; Rudan, Igor ; Lauc, Gordan

Izvornik
Molecular & cellular proteomics (1535-9476) 10 (2011), 1; M110.004200, 7

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
attention deficit hyperactivity disorder (ADHD) ; autism spectrum disorder (ASD) ; plasma

Sažetak
Over a half of all proteins are glycosylated, and their proper glycosylation is essential for normal function. Unfortunately, due to structural complexity of nonlinear branched glycans and the absence of genetic template for their synthesis, the knowledge about glycans is lagging significantly behind the knowledge about proteins or DNA. Using a recently developed quantitative high throughput glycan analysis methods we quantified components of the plasma N‐glycome in 99 children with attention‐deficit hyperactivity disorder (ADHD), 81 child and 5 adults with autism spectrum disorder (ASD) and total of 340 matching healthy controls. No changes in plasma glycome were found to associate with ASD, but several highly significant associations were observed with ADHD. Further structural analysis of plasma glycans revealed that ADHD is associated with increased antennary fucosylation of biantennary glycans and decreased levels of some complex glycans with three or four antennas. The design of this study prevented any functional conclusions about the observed associations, but specific differences in glycosylation appears to be strongly associated with ADHD what warrants further studies into this direction.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA

Projekti:
MZOS-098-0982522-2455 - Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja (Pivac, Nela, MZOS ) ( CroRIS)
MZOS-098-0982522-2457 - Farmakogenomika i proteomika serotoninskog i kateholaminskog sustava (Muck-Šeler, Dorotea, MZOS ) ( CroRIS)
MZOS-108-1081874-1923 - Genomska analiza transkriptoma i interaktoma u bolesnika s kompleksnim bolestima (Borovečki, Fran, MZOS ) ( CroRIS)
MZOS-216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Polašek, Ozren, MZOS ) ( CroRIS)
309-0061194-2023 - Glikoproteomika stresa i bolesti povezanih sa stresom

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Osijek,
Medicinski fakultet, Split,
GENOS d.o.o.

Profili:

Matea Nikolac Perković (autor)