Naslov
Parvovirus B19 (PVB19) induced pure red cell aplasia (PRCA) in immunocompromised patient after liver transplantation

Autori
Mrzljak, Anna ; Kardum-Skelin, Ika ; Čolić-Cvrlje, Vesna ; Filipec Kanižaj, Tajana ; Šušterčić, Dunja ; Guštin, Denis ; Kocman, Branislav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Knjiga sažetaka 4. Hrvatski kongres kliničke citologije, 1. Hrvatski simpozij analitičke citologije i 2. Hrvatski simpozij citotehnologije s međunarodnim sudjelovanjem / Kardum-Skelin, Ika ; Batinić, Drago ; Anić, Veronika - , 2009

Skup
4. Hrvatski kongres kliničke citologije, 1. Hrvatski simpozij analitičke citologije i 2. Hrvatski simpozij citotehnologije s međunarodnim sudjelovanjem

Mjesto i datum
Split, Hrvatska, 11.04.2009. - 14.04.2009

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
PVB19; PRCA; liver transplantation

Sažetak
Presented here is a case of human parvovirus B19 (PVB19) induced pure red-cell aplasia (PRCA) in immunocompromised patient after orthotopic liver transplantation (OLT). PVB19 is a small, single- stranded DNA whose target cell is the erythroid progenitor in bone marrow. Manifestations of PVB19 infection vary with the immunologic status of the patient, ranging from asymptomatic to severe infections and PRCA. Post-transplant PRCA is induced either by immunosuppressive agents or PVB19. In the presented case, bone marrow aspiration characterized by the absence of mature erythroid precursors and detection of PVB19 DNA in blood led to treatment with high-dose intravenous human immunoglobulins (IVIG) and subsequent recovery of erythropoiesis. Due to insufficient antibody response in immunocompromised patients, suppression of the PVB19 infection is delayed and repetitive treatments may be administrated in attempt of reversing PRCA.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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