Naslov
Treatment of hepatocellular carcinoma with liver transplantation – experience at Clinical Hospital Merkur

Autori
Mikulić, Danko ; Jadrijević, Stipislav ; Škopljanac, Andrija ; Kocman, Ivica ; Suknaić, Slaven ; Mrzljak, Anna ; Kocman, Branislav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
European surgery / - : Springer, 2010, 11-11

Skup
Central European Congress of Surgery, Norman Barrett Symposium (3 ; 2009) ;

Mjesto i datum
Dubrovnik, Hrvatska, 28.04.2009. - 01.05.2009

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
hepatocellular carcinoma; liver transplantation

Sažetak
Orthotopic liver transplantation (OLT) is the most efficient option for the treatment of hepatocellular carcinoma(HCC) in terms of survival and recurrence rate provided that restrictive selection criteria are applied. However, tumor recurrence occurs in 3.5–30% of recipients and it has a negative impact on prognosis. In this retrospective study we analyzed survival and tumor recurrence rate in a cohort of patients with HCC treated with OLT in a single center. Between 2005 and 2009 30 patients with HCC were transplanted. Mean age was 58þ5.28 years. Twenty-two patients were male and 8 were female. Etiology was viral in 12 patients (30%), alcoholic in 14 (46.6%) and miscellaneous in 4 patients (13.3%). After a median follow-up of 30.8 months, 25 recipients(83.3%) were alive. Eight patients (26.6%) had disease recurrence. Twenty-one patients (70%) were transplanted within and 9 patients (30%) were outside Milan criteria. A higher recurrence rate was noted in patients surpassing the Milan criteria. OLT is an effective mode of treatment for patients with HCC providing low recurrence rates and survival comparable to liver transplantation for benign disease if restrictive selection criteria are applied

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA