Naslov
Extraovarian steroid cell tumor "not otherwise specified" as a rare cause of virilization in twelve-year-old girl

Autori
Dumić, Miroslav ; Šimunić, Velimir ; Ilić-Forko, Jadranka ; Cvitanović, Marijana ; Plavšić, Vesna ; Ille, Jasenka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
... ; u: Revue Endokrinologie 3 (2000) ; 210-211 / - , 2000, 210-211

Mjesto i datum
,

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
child; female; human; ovary; retroperitoneal neoplasms - complications; retroperitoneal neoplasms - pathology; retroperitoneal neoplasms - surgery; virilism - etiology

Sažetak
We present a 12-year-old girl with a 5-year history of progressive virilization. Regarding elevated plasma levels of 17-hydroxyprogesterone (17-OHP) and androgens, normal ultrasound and CT scan of ovaries and adrenal glands, the nonclassic form of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency was presumed the cause of virilization. As the glucocorticoid therapy did not normalize high levels of 17-OHP and androgens, and the DNA analysis did not demonstrate a mutation causing CAH, a laparotomy was performed. Near the right ovary a tumor was found and extirpated. Pathohistological studies determined it to be a rare steroid cell tumor, 'not otherwise specified'. Within the next months the signs of virilization resolved and menarche occurred. Steroid cell tumor should be considered in differential diagnosis of virilization in childhood. Regarding the age of our patient and pathohistological findings of the tumor, her prognosis is favorable.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Molim HITNO upotpuniti zapis svim obveznim podacima, hvala, admin (2007-10-19), ponovno 2008-08-22!

POVEZANOST RADA