Naslov
Topical Uptake of Guanidino Compound NC1 and N-Acetyl-Cysteine Into Rabbit and hSVCT2 Mouse Lens for the Prevention of Senile Cataracts

Autori
Monnier, Vincent M. ; Fan, Xinjun ; Liu, Xiaoqin ; Potts, B.-S., Strauch, Christopher ; Nemet, Ina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Skup
The Association for Research in Vision and Ophthalmology ARVO, annual meeting

Mjesto i datum
Fort Lauderdale (FL), Sjedinjene Američke Države, 02.05.2010. - 06.05.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Cataracts; Lens Crystallins; Aggregation

Sažetak
Senile cataracts are strongly associated with postsynthetic modifications of lens crystallins by advanced ascorbylation end products that are known to enhance crystallin aggregation and light scattering. Guanidino compound NC1 fed to hSVCT2 mice was previously found to block ascorbylation reactions (Fan et al, IOVS 49:4945-52, 2008). As a preamble to the topical application of NC1 as a drug applied to the human eye, we have compared the uptake of NC1 and N-acetyl-cysteine (NAC) in rabbit lens in vitro and in vivo, as well as the ability of NC1 to block ascorbylation when applied topically to hSVCT2 mouse model of lenticular aging. Guanidino compound NC1 is readily taken up via topical application to the lens, in contrast to NAC which suppressed only fluorescence. This, with the broad ability of NC1 to inhibit undesirable crystallin modifications, opens up the possibility of testing the anticataract potential of NC1 in clinical trial.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA