Pretraga

Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 485777

Partial characterization of the molecular nature of collagen-linked fluorescence : Role of diabetes and end-stage renal disease

Sell, David R.; Nemet, Ina; Monnier, Vincent M.
Partial characterization of the molecular nature of collagen-linked fluorescence : Role of diabetes and end-stage renal disease // Archives of biochemistry and biophysics, 493 (2010), 2; 192-206 doi:10.1016/j.abb.2009.10.013 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 485777 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Partial characterization of the molecular nature of collagen-linked fluorescence : Role of diabetes and end-stage renal disease

Autori
Sell, David R. ; Nemet, Ina ; Monnier, Vincent M.

Izvornik
Archives of biochemistry and biophysics (0003-9861) 493 (2010), 2; 192-206

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
aging; glycation; skin; structure; marker; diabetes; renal disease

Sažetak
Collagen-linked fluorescence at excitation/emission 370/440 nm has widely been used as a marker for advanced glycation in studies of aging, diabetic complications, and end-stage renal disease (ESRD). Diagnostic devices measuring skin autofluorescence at this wavelength revealed an association between fluorescence and cardiovascular morbidity and mortality. We now report the presence of a major fluorophore (LW-1) in human skin collagen which increases with age, diabetes, and ESRD. It has a molecular weight of 623.2 Da, a UV maximum at 348 nm, and involves a lysine residue in an aromatic ring. LW-1 could not be synthesized using traditional glycation chemistry suggesting a complex mechanism of formation, perhaps related to hypoxia since elevated levels were also found in nondiabetic individuals with chronic lung disease.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA

Projekti:
098-0982933-2936 - Kemijske preobrazbe prirodnih spojeva (Varga-Defterdarović, Lidija, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Ina Nemet (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com www.sciencedirect.com

Citiraj ovu publikaciju:

Sell, David R.; Nemet, Ina; Monnier, Vincent M.
Partial characterization of the molecular nature of collagen-linked fluorescence : Role of diabetes and end-stage renal disease // Archives of biochemistry and biophysics, 493 (2010), 2; 192-206 doi:10.1016/j.abb.2009.10.013 (međunarodna recenzija, članak, znanstveni)
Sell, D., Nemet, I. & Monnier, V. (2010) Partial characterization of the molecular nature of collagen-linked fluorescence : Role of diabetes and end-stage renal disease. Archives of biochemistry and biophysics, 493 (2), 192-206 doi:10.1016/j.abb.2009.10.013.
@article{article, author = {Sell, David R. and Nemet, Ina and Monnier, Vincent M.}, year = {2010}, pages = {192-206}, DOI = {10.1016/j.abb.2009.10.013}, keywords = {aging, glycation, skin, structure, marker, diabetes, renal disease}, journal = {Archives of biochemistry and biophysics}, doi = {10.1016/j.abb.2009.10.013}, volume = {493}, number = {2}, issn = {0003-9861}, title = {Partial characterization of the molecular nature of collagen-linked fluorescence : Role of diabetes and end-stage renal disease}, keyword = {aging, glycation, skin, structure, marker, diabetes, renal disease} }
@article{article, author = {Sell, David R. and Nemet, Ina and Monnier, Vincent M.}, year = {2010}, pages = {192-206}, DOI = {10.1016/j.abb.2009.10.013}, keywords = {aging, glycation, skin, structure, marker, diabetes, renal disease}, journal = {Archives of biochemistry and biophysics}, doi = {10.1016/j.abb.2009.10.013}, volume = {493}, number = {2}, issn = {0003-9861}, title = {Partial characterization of the molecular nature of collagen-linked fluorescence : Role of diabetes and end-stage renal disease}, keyword = {aging, glycation, skin, structure, marker, diabetes, renal disease} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

Citati:

    Altmetrijski pokazatelji:


    Podijeli:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font
    CROSBI koristi kolačiće (cookies) kako bi poboljšao funkcionalnost stranice.