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Pregled bibliografske jedinice broj: 485771

Anaerobic vs aerobic pathways of carbonyl and oxidant stress in human lens and skin during aging and in diabetes : A comparative analysis

Fan, Xingjun; Sell, David R.; Zhang, Jianye; Nemet, Ina; Theves, Mathilde; Lu, Jie; Strauch, Christopher; Halushka, Marc K.; Monnier, Vincent M.
Anaerobic vs aerobic pathways of carbonyl and oxidant stress in human lens and skin during aging and in diabetes : A comparative analysis // Free radical biology & medicine, 49 (2010), 5; 847-856 doi:10.1016/j.freeradbiomed.2010.06.003 (međunarodna recenzija, članak, znanstveni)

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Naslov
Anaerobic vs aerobic pathways of carbonyl and oxidant stress in human lens and skin during aging and in diabetes : A comparative analysis

Autori
Fan, Xingjun ; Sell, David R. ; Zhang, Jianye ; Nemet, Ina ; Theves, Mathilde ; Lu, Jie ; Strauch, Christopher ; Halushka, Marc K. ; Monnier, Vincent M.

Izvornik
Free radical biology & medicine (0891-5849) 49 (2010), 5; 847-856

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
crystallins; collagen; glycation; oxidative stress; methylglyoxal; metals; free radicals

Sažetak
The effects of anaerobic (lens) vs aerobic (skin) environment on carbonyl and oxidant stress are compared using de novo and existing data on advanced glycation and oxidation products in human crystallins and collagen. Almost all modifications increase with age. Methylglyoxal hydroimidazolones, carboxymethyllysine, and carboxyethyllysine are severalfold higher in lens than in skin and markedly increase upon incubation of lens crystallins with 5 mM ascorbic acid. In contrast, fructose-lysine, glucosepane crosslinks, glyoxal hydroimidazolones, metal-catalyzed oxidation (allysine), and H2O2-dependent modifications (2-aminoapidic acid and methionine sulfoxide) are markedly elevated in skin, but relatively suppressed in the aging lens. In both tissues ornithine is the dominant modification, implicating arginine residues as the principal target of the Maillard reaction in vivo. Diabetes (here mostly type 2 studied) increases significantly fructose-lysine and glucosepane in both tissues (P˂0.001) but has surprisingly little effect on the absolute level of most other advanced glycation end products. However, diabetes strengthens the Spearman correlation coefficients for age-related accumulation of hydrogen peroxide-mediated modifications in the lens. Overall, the data suggest that oxoaldehyde stress involving methylglyoxal from either glucose or ascorbate is predominant in the aging noncataractous lens, whereas aging skin collagen undergoes combined attack by nonoxidative glucose-mediated modifications, as well as those from metal-catalyzed oxidation and H2O2.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA

Projekti:
098-0982933-2936 - Kemijske preobrazbe prirodnih spojeva (Varga-Defterdarović, Lidija, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Ina Nemet (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com www.sciencedirect.com

Citiraj ovu publikaciju:

Fan, Xingjun; Sell, David R.; Zhang, Jianye; Nemet, Ina; Theves, Mathilde; Lu, Jie; Strauch, Christopher; Halushka, Marc K.; Monnier, Vincent M.
Anaerobic vs aerobic pathways of carbonyl and oxidant stress in human lens and skin during aging and in diabetes : A comparative analysis // Free radical biology & medicine, 49 (2010), 5; 847-856 doi:10.1016/j.freeradbiomed.2010.06.003 (međunarodna recenzija, članak, znanstveni)
Fan, X., Sell, D., Zhang, J., Nemet, I., Theves, M., Lu, J., Strauch, C., Halushka, M. & Monnier, V. (2010) Anaerobic vs aerobic pathways of carbonyl and oxidant stress in human lens and skin during aging and in diabetes : A comparative analysis. Free radical biology & medicine, 49 (5), 847-856 doi:10.1016/j.freeradbiomed.2010.06.003.
@article{article, author = {Fan, Xingjun and Sell, David R. and Zhang, Jianye and Nemet, Ina and Theves, Mathilde and Lu, Jie and Strauch, Christopher and Halushka, Marc K. and Monnier, Vincent M.}, year = {2010}, pages = {847-856}, DOI = {10.1016/j.freeradbiomed.2010.06.003}, keywords = {crystallins, collagen, glycation, oxidative stress, methylglyoxal, metals, free radicals}, journal = {Free radical biology and medicine}, doi = {10.1016/j.freeradbiomed.2010.06.003}, volume = {49}, number = {5}, issn = {0891-5849}, title = {Anaerobic vs aerobic pathways of carbonyl and oxidant stress in human lens and skin during aging and in diabetes : A comparative analysis}, keyword = {crystallins, collagen, glycation, oxidative stress, methylglyoxal, metals, free radicals} }
@article{article, author = {Fan, Xingjun and Sell, David R. and Zhang, Jianye and Nemet, Ina and Theves, Mathilde and Lu, Jie and Strauch, Christopher and Halushka, Marc K. and Monnier, Vincent M.}, year = {2010}, pages = {847-856}, DOI = {10.1016/j.freeradbiomed.2010.06.003}, keywords = {crystallins, collagen, glycation, oxidative stress, methylglyoxal, metals, free radicals}, journal = {Free radical biology and medicine}, doi = {10.1016/j.freeradbiomed.2010.06.003}, volume = {49}, number = {5}, issn = {0891-5849}, title = {Anaerobic vs aerobic pathways of carbonyl and oxidant stress in human lens and skin during aging and in diabetes : A comparative analysis}, keyword = {crystallins, collagen, glycation, oxidative stress, methylglyoxal, metals, free radicals} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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