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Pregled bibliografske jedinice broj: 485400

Non-vertebrate animals have only one gene of the p53 family which is most similar to vertebrate p63

Štifanić, Mauro; Baričević, Ana; Batel, Renato
Non-vertebrate animals have only one gene of the p53 family which is most similar to vertebrate p63 // Comparative Biochemistry and Physiology, Part A, Vol. 157, Suppl.1 / Mommsen, T.P. ; Walsh, P.J. (ur.).
Amsterdam: Elsevier, 2010. str. S23-S23 doi:10.1016/j.cbpa.2010.06.063 (predavanje, međunarodna recenzija, sažetak, znanstveni)

CROSBI ID: 485400 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Non-vertebrate animals have only one gene of the p53 family which is most similar to vertebrate p63

Autori
Štifanić, Mauro ; Baričević, Ana ; Batel, Renato

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Comparative Biochemistry and Physiology, Part A, Vol. 157, Suppl.1 / Mommsen, T.P. ; Walsh, P.J. - Amsterdam : Elsevier, 2010, S23-S23

Skup
27. ESCPB Congress: "Biological effects of climatic changes and pollution: from biomarkers to system biology"

Mjesto i datum
Alessandria, Italija, 05.09.2010. - 09.09.2010

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
p53 family ; p63 ; mollusca ; Mytilus

Sažetak
Genes of the p53 family are known to be critical regulators of the cell cycle. They have already been established as possible biomarkers. Elaborate regulation mechanisms result in numerous mRNA and protein isoforms being expressed from each gene of the family. A relatively recent discovery of p53 paralogs (p63 and p73) and high similarity of isoforms expressed from all three p53 family genes caused confusion in their nomenclature in non-vertebrate species. We analyzed all molluscan p53-similar sequences found in the GenBank database and compared their sequences and genomic structures to p53 family genes from other animals. Our results lead to the conclusion that invertebrates have only one gene of the p53 family which radiated into three genes only in vertebrates. This ancestral (molluscan) p53 family gene shows to be most similar to p63 in vertebrates. Furthermore, our analyses indicate p53 family genes to be single-copy genes thus increasing their value as potential biomarkers.

Izvorni jezik
Engleski

Znanstvena područja
Geologija, Biologija



POVEZANOST RADA

Projekti:
098-0982705-2724 - Učinak zagađenja na programirane biosinteze morskih beskralješnjaka (Batel, Renato, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Renato Batel (autor)

Avatar Url Ana Baričević (autor)

Avatar Url Mauro Štifanić (autor)

Poveznice na cjeloviti tekst rada:

doi doi.org www.sciencedirect.com

Citiraj ovu publikaciju:

Štifanić, Mauro; Baričević, Ana; Batel, Renato
Non-vertebrate animals have only one gene of the p53 family which is most similar to vertebrate p63 // Comparative Biochemistry and Physiology, Part A, Vol. 157, Suppl.1 / Mommsen, T.P. ; Walsh, P.J. (ur.).
Amsterdam: Elsevier, 2010. str. S23-S23 doi:10.1016/j.cbpa.2010.06.063 (predavanje, međunarodna recenzija, sažetak, znanstveni)
Štifanić, M., Baričević, A. & Batel, R. (2010) Non-vertebrate animals have only one gene of the p53 family which is most similar to vertebrate p63. U: Mommsen, T. & Walsh, P. (ur.)Comparative Biochemistry and Physiology, Part A, Vol. 157, Suppl.1 doi:10.1016/j.cbpa.2010.06.063.
@article{article, author = {\v{S}tifani\'{c}, Mauro and Bari\v{c}evi\'{c}, Ana and Batel, Renato}, year = {2010}, pages = {S23-S23}, DOI = {10.1016/j.cbpa.2010.06.063}, keywords = {p53 family, p63, mollusca, Mytilus}, doi = {10.1016/j.cbpa.2010.06.063}, title = {Non-vertebrate animals have only one gene of the p53 family which is most similar to vertebrate p63}, keyword = {p53 family, p63, mollusca, Mytilus}, publisher = {Elsevier}, publisherplace = {Alessandria, Italija} }
@article{article, author = {\v{S}tifani\'{c}, Mauro and Bari\v{c}evi\'{c}, Ana and Batel, Renato}, year = {2010}, pages = {S23-S23}, DOI = {10.1016/j.cbpa.2010.06.063}, keywords = {p53 family, p63, mollusca, Mytilus}, doi = {10.1016/j.cbpa.2010.06.063}, title = {Non-vertebrate animals have only one gene of the p53 family which is most similar to vertebrate p63}, keyword = {p53 family, p63, mollusca, Mytilus}, publisher = {Elsevier}, publisherplace = {Alessandria, Italija} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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