Naslov
Inflammatory markers in Alzheimer's disease

Autori
Mück-Šeler, Dorotea ; Mustapić, Maja ; Presečki, Paula ; Mimica, Ninoslav ; Pivac, Nela ; Folnegović Šmalc, Vera

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Neurologia Croatica 59 (Suppl. 2) - Abstracts of the 5th Croatian Congress on Alzheimer's Disease with International Participation / Šimić, Goran ; Mimica, Ninoslav - Zagreb : Denona, 2010, 34-34

Skup
5th Croatian Comgress on Alzheimer's disease with International Participation

Mjesto i datum
Zadar, Hrvatska, 22.09.2010. - 25.09.2010

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
Alzheimer's disease; interleukin1; interleukin 6; interleukin 10; ApoE4; gene polymorphism

Sažetak
Aim. Literature data suggest that the inflammation-related mechanisms could be involved in the pathogenesis of neurodegenerative disorders like Alzheimer's disease (AD). The immunohistochemical studies have shown the co-localization of amyloid plaques and inflammation-related proteins (complement factors, acute-phase proteins, cytokines) in the brain clusters of activated microglia. Interleukin 1α, 1β (IL-1α, IL-1β), interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-α) belong to the pro- inflammatory cytokines, while interleukin 10 (IL-10) is an anti- inflammatory cytokine. These cytokines are the important mediators of inflammatory processes, related to neuropathology of the neuronal cell death. The aim of the study was to determine the genetic variants of cytokine and ApoE genes in patients with AD and healthy controls. Methods. The study included 207 patients with AD and 90 sex and age matched control subjects. The cytokine and ApoE gene polymorphisms were genotyped by TaqMan Real-time allelic discrimination technique after extraction of DNA from whole blood with salting out procedure. Results. A significant difference in IL-10 allele frequency was observed between patients with AD and healthy control. IL-10 (rs1800629) T allele (low producer of IL-10) was significantly decreased in the patient with AD when compared with control subjects. There was no association between genetic variants of other cytokines and AD. The genetic risk factor for AD i.e. the E4 allele of the ApoE gene polymorphism was more frequent in patients with AD than in healthy controls. The 23% of patients with AD were ApoE-E4 allele and IL-10-T allele carriers, while 68% of patients were at least one ApoE-E4 allele and IL- 10-T allele carriers. Conclusion. Our results showed the association between genetic variant of anti-inflammatory cytokine IL-10 and AD suggesting that the decreased formation i.e. lower expression of IL-10, could contribute to immunological mechanisms responsible for the development of AD. Further studies are needed for the better understanding of the inflammatory and immunoregulatory processes in AD, and for the development of anti-inflammatory treatment approaches that could slow the progression or delay the onset of AD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

Napomena
Časopis Neurologia Croatica je indeksiran u Neuroscience Citation Index ; EMBASE/Excerpta Medica.

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