Naslov
Genetic Markers of Coronary Heart Disease

Autori
Stavljenić-Rukavina, Ana ; Sertić, Jadranka ; Salzer, Branka ; Zrinski, Renata ; Krajina, Andina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Proceedings of the XVI International Congress of Clinical Chemistry / Martin, Susan M. ; Halloran, Stephen P. - London : Delhi : The Association of Clinical Chemists, 1996, 232-233

Skup
XVI International Congress of Clinical Chemistry

Mjesto i datum
London, Ujedinjeno Kraljevstvo, 08.07.1997. - 12.07.1997

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
coronary heart disease; genetic markers

Sažetak
Coronary heart disease (CHD) is the main cause of death in the world. Among several inherent factors contributing to the development of atherosclerosis in CHD, abnormalities in lipid metabolism and hypertension probably play important, if not crucial, roles. Lipoprotein molecular markers Lp(a) and apo E together with newer candidates associated with CHD by unknown mechanisms such as angiotensin converting enzyme (ACE) polymorphism have been investigated to reach understanding of factors underlying the genetic basis of this multifactorial disorder. In this study, 50 patients with myocardial infarction were studied for apo E genotype, ACE gene typing and Lp(a) levels. The frequency of apo E genotypes due to allelic variation at amino acids 112 and 158 and ACE polymorphism were analysed by PCR technology. Lp(a) was quantified using rabbit antisera that were monospecific for the Lp(a) antigen. Results revealed 20% of the patients to be E4/4 homozygotes indicating an increased prevalence of E4/4 homozygosity as compared to control subjects (2%) and suggesting its probably atherogenic role in CHD. Results of ACE genotypes showed 42% of the study patients to be homozygous for the DD, 26% for II and 32% for ID allele. The frequency of the I and D alleles in patients was 0.42 and 0.58. The synthesis and metabolism of Lp(a) in the E4/4 genotype appears to shed some light upon the problem, suggesting an association between these two parameters.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA