Naslov
The impact of restricted amoxicillin/clavulanate use on E. coli resistance. Antibiotic DU90% profiles with bacterial resistance rates : A visual presentation

Autori
Mimica Matanović, Suzana ; Bergman, Ulf ; Vuković, Dubravka ; Wettermark, Bjorn ; , Vlahović-Palčevski, Vera

Izvornik
International journal of antimicrobial agents (0924-8579) 36 (2010), 4; 369-373

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
antibiotic use; resistance; quality assessment; hospital care

Sažetak
High use of amoxicillin/clavulanic acid (AMC) at the University Hospital Osijek (Croatia) contributed to high rates of resistance in Enterobacteriaceae, in particular Escherichia coli (50%). Thus, in order to decrease bacterial resistance, AMC use was restricted. We present results of the restriction on resistance amongst antibiotics accounting for 90% of antibiotic use [drug utilisation 90% (DU90%)]. Data were analysed on antibiotic use and microbiological susceptibility of E. coli during two 9-month periods, before and after the restriction of AMC use. Drug use was presented as numbers of defined daily doses (DDDs) and DDDs/100 bed-days. Resistance of E. coli to antibiotics was presented as percentages of isolated strains in the DU90% segment. Use of AMC was 16 DDDs/100 bed-days or 30% of all antibiotics before the intervention. Use of AMC fell to 2 DDDs/100 bed-days or 4% after the intervention, and resistance of E. coli fell from 37% to 11%. In conclusion, restricted use of AMC resulted in a significant decrease of E. coli resistance. DU90% resistance profiles are simple and useful tools in highlighting problems in antibiotic use and resistance but may also be useful in long-term follow-up of antibiotic policy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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