Naslov
Cerebral Palsy in Children with Congenital Cytomegalovirus Infection

Autori
Mejaški-Bošnjak, Vlatka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The 16th Mediterranean Meeting of Child Neurology : abstracts / - , 2010, 30-30

Skup
Mediterranean Meeting of Child Neurology (16 ; 2010)

Mjesto i datum
Mikonos, Grčka, 23.09.2010. - 26.09.2010

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cerebral palsy; congenital cytomegalovirus infection

Sažetak
Congenital cytomegalovirus (CMV) infection is the most common transplacentary transmitted infection. It may cause wide range of neurodevelopmental disorders, including cerebral palsy (CP). We present nine patients with proven congenital CMV infection, suffering cerebral palsy and their clinical assessments along with computed tomography/magnetic resonance (CT/MRI) findings. Patients (3 boys, 6 girls) were referred from neonatal age to the age of 11 months. Congenital CMV infection was confirmed in all children by serology tests and/or polymerase chain reaction for CMV DNA in serum and/or isolation of CMV virus from urine. All 9 children had prospective neurodevelopmental follow up, undergoing repeated neurological, hearing and ophthalmologic investigations, developmental assessment including speech and behaviour, with final assessment at the age of 6 to 15 years of age respectively. Classification of CP was performed accordig to Surveillance of Cerebral Palsy Europe (SCPE) proposal. Cranial CT and/or MRI were performed on all of the patients. Eight of our patients had symptomatic infection at birth, and only one was asymptomatic. Four children had diskinetic and five had bilateral spastic CP. All of children had microcephaly, six of nine developed epilepsy, chorioretinitis was found in three and sensorineural deafness in five children. Two additionally had autistic behaviour. Neuroimaging showed in five children complex brain malformations: pachy/polymicrogyria, hypoplastic cerebellum, callosal agenesis/hypoplasia, paraventricular cyst and calcifications. Another three had multofocal leukoencephalopathy with temporal cysts. In only asymptomatic child repeaded MRI demonstrated brain atrophy. Congenital CMV infection causes multiorgan affection, but the most severe and permanent sequelae are those affecting central nervous system. Therefore, it should be considered more often at neonatal age because of its significant role in a wide variety of neurological disabilities later in childhood.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA