Naslov
Prediction of nonlinear gradient signal in ion chromatography based on “experiment-free” methodology

Autori
Bolanča, Tomislav ; Ukić, Šime ; Rogošić, Marko

Izvornik
Journal of liquid chromatography & related technologies (1082-6076) 33 (2010), 20; 1831-1841

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ion chromatography ; nonlinear gradient ; signal prediction

Sažetak
One of the strategies that might be applied in ion chromatographic (IC) multi-segment gradient optimization is the simplification of gradient profile and its approximation by nonlinear elution. This work describes the IC signal modeling strategy for linear and nonlinear gradients. The performance characteristics of developed models do not depend on the linearity of gradient profile, but rather on initial gradient of eluent competing ion concentration. Four different IC models are developed and tested, requiring three, two or single experimental data point. Moreover, a model based on “experiment-free” methodology using standard column manufacturer quality assurance documents is developed. It is shown that all the developed models have good predictive ability that decreases by reducing the model complexity and number of experimental data required. However, even the “experiment-free” methodology offers reasonable performance characteristics (average of relative error 4.99 %) and might be recommended for IC method development purposes.

Izvorni jezik
Engleski

Znanstvena područja
Kemijsko inženjerstvo

POVEZANOST RADA