Naslov
Close links of bone and adipose tissue

Autori
Grizelj, Danijela ; Vrljić, Dubravka ; Bušić, Nikša ; Pandžić Jakšić, Vlatka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts, 1st International Conference on Regenerative Orthopaedics / - , 2010

Skup
1st International Conference on Regenerative Orthopaedics (ICR0)

Mjesto i datum
Zagreb, Hrvatska, 02.07.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
obesity; bone mineral density; osteocalcin; 25OH-vitamin D

Sažetak
Besides sharing the same origin from the common mesenchymal stem cell, bone and adipose tissue show complex interactions. With the discovery of adipocytokines, an active role of adipose tissue in bone remodeling has been revealed. Recent data however suggest that this process might also be reverse and factors secreted by bone might influence energy balance. We have studied a group of 50 women referred to endocrinologist for osteoporosis evaluation. Anthropometric measures were collected and bone densitometry was performed. Laboratory analysis included metabolic parameters: glucose, triglycerides, HDL-cholesterol, LDL-cholesterol, C-reactive protein, 25OH-vitamin D as well as bone turnover markers: osteocalcin, beta-C-terminal telopeptide of type I collagen and bone alkaline phosphatase. Following results have been obtained by nonparametric statistical analysis. Significant positive correlations were found between anthropometric measures of obesity and bone mineral density in total and femoral neck (p<0, 05), but not in lumbar spine. 25-OH vitamin D was negatively associated with body mass index and waist circumference (p<0, 05). The study sample was also divided in three groups according to the World Health Organization classification of body mass index. Besides significant differences in metabolic parameters and femoral bone mineral density, the obese group had also lower levels of osteocalcin (p<0, 05). These results support close links of bone mineral density and obesity. They probably reflect experimental data that show the skeleton as a source of hormone-like substances like osteocalcin that interfere with energy metabolism.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA