Naslov
Antifungal activity of Lavandula x intermedia Emeric ex Loisel. 'Budrovka'

Autori
Blažeković, Biljana ; Pepeljnjak, Stjepan ; Stanić, Gordana ; Vladimir-Knežević, Sanda

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Planta Medica / Melzig, Matthias F. ; Kolodziej, Herbert - Stuttgart : Georg Thieme Verlag, 2010, 1307-1308

Skup
58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research

Mjesto i datum
Berlin, Njemačka, 29.08.2010. - 02.09.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Lavandula x intermedia Emeric ex Loisel. 'Budrovka'; antifungal activity; zones of inhibition of fungal growth; minimal inhibitory concentration; minimal fungicidal concentration

Sažetak
Lavandula x intermedia Emeric ex Loisel. 'Budrovka' is an indigenous cultivar of lavandin which has been widely cultivated in Croatia as an essential oil crop. Our previous studies revealed strong antioxidant and antibacterial activities of its various extracts [1, 2]. Continuing our evaluation of biomedical potential of lavandin ’Budrovka’, the present work focuses on the investigation of antifungal activity. For this purpose, liquid ethanolic extracts were prepared from different plant parts: flowers, inflorescence stalks and leaves. Employing the agar-well diffusion method, the extracts were screened for antifungal activity against eight yeast strains (Candida albicans, C. glabrata, C. krusei, C. kefyr, C. tropicalis, Cryptococcus neoformans, Blastoschizomyces capitatus and Hansenula anomala) and five molds (Aspergillus fumigatus, A. niger, Fusarium oxysporum, Penicillium citrinum and Trichoderma viride). Overall, the tested extracts were more effective against yeasts then molds. The measured zones of inhibition of fungal growth strongly indicated that the antifungal constituents reside primarily in the flower (ZI: 10-21 mm), whereas the inflorescence stalk and leaves extracts exhibited considerably weaker activity (ZI ≤ 10). Minimal inhibitory concentrations (MIC, vol%) and minimal fungicidal concentrations (MFC, vol%) for each strain were determined by the broth dilution assay. Results obtained for flower, leaf and inflorescence stalk extracts revealed that Candida krusei was the most sensitive tested strain (MIC: 0.05, 8 and 9%, respectively), while Aspergillus niger was the most resistant (MIC: 4, 30 and 35%, respectively). In conclusion, the present study highlighted the antifungal potential of Lavandula x intermedia 'Budrovka' flowers. References: 1. Blažeković, B., Vladimir-Knežević, S. (2008) Planta Med. 74:951. 2. Blažeković, B., Pepeljnjak, S., Stanić, G., Žutić, I. (2005) Book of Abstracts of 53 rd Annual Congress of the Society for Medicinal Plant Research. Firenca. Societa italiana di fitochimica, 145.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

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