Pregled bibliografske jedinice broj: 479930
Surface-enhanced Raman study of the interactions between cationic polyamines and polynucleotides
Surface-enhanced Raman study of the interactions between cationic polyamines and polynucleotides // EUCMOS 2010 Book of Abstract / Becucci, Maurizio ; Gellini Cristina ; Schettino Vincenzo (ur.).
Firenza : München, 2010. str. 136-136 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 479930 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Surface-enhanced Raman study of the interactions between cationic polyamines and polynucleotides
Autori
Dijanošić, Adriana ; Miljanić, Snežana ; Meić, Zlatko ; Piantanida, Ivo ; Albelda Teresa M. ; Sornosa-Ten Alejandra ; Garcia-Espana Enrique
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
EUCMOS 2010 Book of Abstract
/ Becucci, Maurizio ; Gellini Cristina ; Schettino Vincenzo - Firenza : München, 2010, 136-136
Skup
XXX European Congress on Molecular Spectroscopy
Mjesto i datum
Firenca, Italija, 29.08.2010. - 03.09.2010
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
spektroskopija površinski pojačanog Ramanovog raspršenja; poliamini; polinukleotidi
(surface-enhanced Raman scattering; polyamines; polynucleotides)
Sažetak
Surface-enhanced Raman scattering (SERS) was used to study interactions of new DNA/RNA binding compounds with double-stranded DNA polynucleotides (poly dAdT-poly dAdT, poly dGdC-poly dGdC) and calf thymus DNA (ct-DNA). SERS experiments with double-stranded polynucleotides revealed strong enhancement of the Raman scattering from the polyamine molecules attached on the colloidal silver particles as well as appearance of new bands associated mainly with nucleobases. Im and Py selectively interact with polynucleotides depending on their base pairs structures. Interactions within both, major and minor groove are recognized for poly dAdT-poly dAdT, while the polyamines prefer binding only to major groove of poly dGdC- poly dGdC. In SERS spectra with ct-DNA downshift of the imidazole and pyridine ring vibrations supports aromatic stacking interactions of the aromatic moieties between the DNA base pairs. Although the same binding mode was evidenced for both molecules, more spectral changes were observed for Im. Since Im and Py contain the same aminomethylene chains in molecular structure, differences originate from the aromatic rings. Unlike pyridine, the imidazole ring poses two potential binding sites, obviously responsible for stronger interactions.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
119-1191342-2959 - Spektroskopska analiza nezasićenih sustava i spojeva metala (Miljanić, Snežana, MZOS ) ( CroRIS)
Ustanove:
Prirodoslovno-matematički fakultet, Zagreb
