Naslov
Novel cage-functionalized building blocks in peptidomimetic design

Autori
Matković, Marija ; Kragol, Goran ; Mlinarić-Majerski, Kata

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
AMP2010 - Australia-Croatia workshop on antimicrobial peptides and summer school in biophysics Phd programme / - Split, 2010, 45-45

Skup
Australia-Croatia workshop on antimicrobial peptides and summer school in biophysics Phd programme

Mjesto i datum
Split, Hrvatska, 09.08.2010. - 14.08.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
adamantane; homoadamantane; peptides; peptidomimetics

Sažetak
Synthetic peptides with antimicrobial activity are a very promising class of compounds for drug discovery. They are often prepared by changing the natural peptide sequence by introducing different structural modifications such as β-peptide bond and/or unusual side chains.[1] Also, many biologically active peptides incorporate hydroxy acids so that the synthesis of an ester instead of a peptide bond stands as a modification.[2] On the other hand adamantane is a well known pharmacophore present in different drugs.[3] Introducing cage molecules such as adamantane and homoadamantane into peptidomimetic structures should generate amphiphilic structures with enhanced possibility of permeation through biomembranes. In the scope of our investigation [4] we have prepared several α-amino and β-hydroxy esters or acids with homoadamantane (1a-1c) and adamantane (2a-2b) as the side chain. These molecules are convenient building blocks for introducing multiple interesting structural modifications in the new peptidomimetics

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA