Naslov
PREDICTING OUTCOME OF HPV INDUCED LOW-GRADE CERVICAL LESION BY IMMUNOASSAYING

Autori
Krivak Bolanča Ines, Šentija Karmela, Katalenić Simon Suzana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Cytopathology //Abstract of the 35th European Congress of Cytopathology / - , 2009

Skup
35TH European Congress of Cytopathology

Mjesto i datum
Lisabon, Portugal, 27.09.2009. - 30.09.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
LSIL; p16INK4a; HPV L1; clinical behavior

Sažetak
It is well known fact that almost all cervical lesions are induced by persistent HPV infection. Incidence of HPV infection among young women is high, but fortunately for them not every infection results with disease. Despite of having good tools for detecting epithelial changes still one can not be sure which lesion will progress, so additional diagnostic or therapeutic efforts must be made. Aim of the study: By performing immunoassaying on slides from cervical smears with cellular protein p16INK4a and viral capsid protein HPV L1 we tried to predict which cervical lesion will progress or regress. Material and examinees: In our study we followed-up 56 patients with abnormal cervical smears by repeating their Pap smears every 6 months for two years after performing immunoassaying. All of the patients were HPV positive. Slides for immunoassay were taken from the archive or simultaneously with initial Pap smear and were stained with p16INK4a and HPV L1 according to manufacture proscriptive. After at least two negative Pap smears we could say that initial cervical lesion regressed. Results: The correlation between L1 and p16 expressions suggests that L1 negative / p16 positive and double positive cases persist or have the potential for progression with one case of regression. All L1 positive cases as well as double negative cases showed regression with 2 cases of persistence. Conclusion: Performing immunoassaying with p16 and L1 can be helpful tool for predicting the behaviour of cervical low grade lesions and to plan the clinical management of these patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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