Naslov
Vulvar paget's disease : a Case Report

Autori
Katalenić Simon, Suzana ; Krivak Bolanča, Ines ; Šentija, Karmela ; Kukura, Vlastimir ; Valetić, Josip ; Škrtić, Anita

Izvornik
Collegium antropologicum (0350-6134) 34 (2010), 2; 649-652

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, prethodno priopćenje, stručni

Ključne riječi
vulvar Padget's disease; Padget's cells; vulvar cytology; immunostaining

Sažetak
Vulvar Morbus Paget's (MP) represents a rare intraepithelial adenocarcinoma. It appears in less than 5% of all vulvar neoplasia ussually in postmenopausalis women. Histological it is analogous to Paget's disease of the breast. The most common clinical symptom is pruritus.The lesions appear as an erythematous or eczematous lesion with islands of hyperkeratosis. Occasionally, single anaplastic Paget's cells can be found on the vulvar smears which make cytological diagnosis of the disease possible. However, the disease can be diagnosed only by biopsy. MP is classified into three distinct type based upon the origin of the neoplastic cell: type I – primary vulvar cutaneus Paget disease ; type II – MP as a manifestation of an associated adjacent primary anal or rectal adenocarcinoma and type III – pagetoid urothelial intraepithelial neoplasia. To distinguish these subtypes the panel of immunohistochemistry markers must be done. We present a case of 49-year old woman with vulvar symptoms of pruritus, who had liver and kidney transplatation a two years ago. During the standard gynaecological examination the vulvar smear was taken for cytological evaluation. The smear was scanty, overload with squamae, with two kinds of cells: dysplastic squamous cells from lower layer of the epithelium and the single, anaplastic cells with enlarged nuclei, visible nucleoli and pale indistinct cytoplasm. According to that cytological diagnosis was vulvar intraepithelial lesions III (VIN III) with differential diagnosis of vulvar Paget disease. The pathological verification support the diagnosis of MP and an immunohistochemistry panel confirm type III of Paget disease so a evaluation of bladder was suggested.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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