Naslov
Influence of lamotrigine on the Na+, K+- ATPase activity and induction of JNK and c-Jun in electroconvulsive shock-treated rats

Autori
Vitezić, Dinko ; Mršić, Jasenka ; Župan, Gordana ; Maysinger, Dušica ; Simonić, Ante

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the2nd European Congress of Pharmacology ; u: Fundamental & Clinical Pharmacology. Supplement 13 (1999) (S1) / - , 1999, 201-201

Skup
European Congress of Pharmacology (23 ; 1999)

Mjesto i datum
Budimpešta, Mađarska, 03.07.1999. - 07.07.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
lamotrigine

Sažetak
The aim of the present study was to investigate the inftuence of the new antiepileptic drug, lamotrigine (LTG), on the Na+, K+- ATPase activity and activation of JNK/c-Jun axis in rat hippocampus after electroconvulsive shock (ECS)-induced conwlsions. Enzime activity and JNK/c-Jun induction in hippocampal tissue were determined after single and multiple (five consecutive days) ECS applications. The same parameters are also determined in rats pretreated with LTG (30 mg/kg) two hours before ECS application. We found that Na+, K+- ATPase activity was significantly inereased after single and after multiple ECS exposures. JNK and c-Jun induction was also observed. In the group of LTG-pretreated rats, LTG prevented changes of Na+, K+- ATPase activity, as well as JNK and c-Jun induction after single ECS treatment. It may be concluded that LTG has a protective effect on the Na+, K+- ATPase activity and early induction of JNK/c-Jun axis.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA