Naslov
Influence of nimodipine and amlodipine on the passive avoidance behaviour in rats exposed to electroconvulsive shock

Autori
Vitezić, Dinko ; Župan, Gordana ; Mršić, Jasenka ; Matešić, Damir ; Simonić, Ante

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Periodicum Biologorum (ISSN:0031-5362), Vol 99, Suppl 1 / Vitale, Branko - Zagreb : Hrvatsko prirodoslovno društvo, 1997, 33-33

Skup
2nd Croatian Congress of Pharmacology with International Participation

Mjesto i datum
Rijeka, Hrvatska, 09.09.1997. - 13.09.1997

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
electroconvulsive shock; nimodipine; amlodipine; passive avoidance

Sažetak
The influence of nimodipine and amlodipine on the learning ability in rats exposed to electroconwlsive shock (ECS) was examined. Various doses (0.03, 0.1, 0.3 or 1.0 mg/kg) of the Ca2+ channel blockers tested had been injected 30 min before the passive avoidance procedure started. The ECS was given immediately after the learning trial response had been acquired. A passive avoidance retention test was performed 24 h later. It was found that ECS strongly impaired the retention of the passive avoidance response. Nimodipine and amlodipine did not influence the passive avoidance behaviour in the sham ECS group, but significantly improved the retention deficits in the animals exposed to ECS. These findings support the hypothesis that perturbations in Ca2+ homeostasis can contribute to the memory deficits associated with ECS administration. The antiamnestic effects of the Ca2+ channel blockers tested make them interesting candidates for clinical trials in patients with cognitive impairment caused by electroconvulsive therapy.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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