Naslov
Malignancy Risk Assessment in Adenomatoid Nodules and Suspicious Follicular Lesions of the Thyroid Obtained by Fine-needle Aspiration Cytology

Autori
Dabelić, Nina ; Mateša, Neven ; Mateša-Anić, Dubravka ; Kusić, Zvonko

Izvornik
Collegium antropologicum (0350-6134) 34 (2010), 2; 349-354

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
thyroid nodule; follicular; fine needle; aspiration cytology

Sažetak
Our aim was to assess malignancy risk in adenomatoid nodules and suspicious follicular lesions of the thyroid obtained by fine needle aspiration (FNA) cytology. Retrospective research was performed of 276 patients (pts) who underwent thyroid surgery after preoperative ultrasound-guided FNA diagnosis of either adenomatoid nodule, cellular follicular lesion, «suspicious for follicular neoplasm» or follicular neoplasm. Out of 276 pts, FNA reports showed 15 diagnoses (5%) of adenomatoid nodules, 73 (26%) cellular follicular lesions, 76 (28%) «suspicious for follicular neoplasm», and 112 diagnoses (41%) of follicular neoplasm. FNA reports were compared with pathohistological findings. In FNA reports of adenomatoid nodule (N=15), there were 7 (47%) pathohistological diagnoses (PHDs) of nodular goiter, and 8 (53%) PHDs of follicular adenoma. In FNA reports of cellular follicular lesion (N=73), there were 2 (3%) PHDs of thyroiditis, 32 (44%) PHDs of nodular goiter, 38 (52%) PHDs of follicular adenoma, and 1 (1%) PHD of papillary carcinoma. In FNA reports of “suspicious for follicular neoplasm” (N=76), there was 1 (1%) PHD of thyroiditis, 24 (32%) PHDs of nodular goiter, 47 (62%) PHDs of follicular adenoma and 4 (5%) diagnoses of papillary carcinoma. In FNA reports of follicular neoplasm (N=112), there were 25 (22%) PHDs of nodular goiter, 72 (64%) PHDs of follicular adenoma, and 15 (14%) PHDs of thyroid carcinoma. We found significant difference (p<0.01) between investigated FNA report groups according to malignancy risk. Stratification of cytologic diagnoses of follicular thyroid lesions into different subcategories with various probabilities of malignancy allows more accurate estimation of malignancy risk and individualized patient treatment, when deciding between immediate operation and close follow-ups with repeat FNA.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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