Naslov
Lamotrigine: influence on the passive avoidance behavior in electroconvulsive shock-treated rats

Autori
Vitezić, Dinko ; Župan, Gordana ; Mršić, Jasenka ; Simonić, Ante

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 5th Congress of the European Society for Clinical Neuropharmacology ; u: Journal of Neural Transmission. Supplement 107 (2000) (S) / - , 2000, 40-41

Skup
Congress of the European Society for Clinical Neuropharmacology (5 ; 2000)

Mjesto i datum
Opatija, Hrvatska, 17.05.2000. - 21.05.2000

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
lamotrigine; electroconvulsive shock

Sažetak
Lamotrigine (LTG) is an antiepileptic drug with the actions at the neuronal voltage-gated sodium channel and as a glutamate release inhibitor. The effects of various doses (1, 10 or 30 mg/kg) of LTG on the learning ability in rats exposed to electroconvulsive shock (ECS) were examined. The animals were trained in a passive avoidance procedure. LTG had been injected 30 min before the leaming trial started. The electroconvulsive shock was given immediately after the leaming trial response had been acquired. A passive avoidance retention test was performed 24 hours later. It was found that ECS strongly impaired the retention of the passive avoidance response. LTG did not influence the passive avoidance behavior in the sham ECS group. Retention deficit in the animals exposed to ECS were significantly improved with LTG in the doses of 10 and 30 mg/kg. In conclusion, these findings support the hypothesis that perturbations in ionic homeostasis and excessive glutamate release can contribute to the memory deficits associated with ECS administration. Because of the antiamnestic effect, LTG can be an interesting candidate for clinical trials in patients with cognitive impairment causes by electroconvulsive therapy.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA