Naslov
Lamotrigine: Influence on the activity of Na+, K+-ATPase, JNK and c-Jun induction in rat hippocampus after kainic acid treatment

Autori
Vitezić, Dinko ; Mršić, Jasenka ; Župan, Gordana ; Maysinger, Dušica ; Simonić, Ante

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 23rd International Epilepsy Congress ; u: Epilepsia. Supplement 40 (1999) (S2) / - , 1999, 119-119

Skup
International Epilepsy Congress (23 ; 1999)

Mjesto i datum
Prag, Češka Republika, 12.09.1999. - 17.09.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
lamotrigine; hippocampus

Sažetak
We examined the effects of lamotrigine (LTG) on the activity of Na+, K+-ATPase, and stress- activated protein kinase, c-Jun N-terminal kinase (JNK) and induction of c-Jun protein in rat hippocampus after kainic acid (KA) treatment. Enzyme activity from hippocampal tissue was detarmined two hours, three and five days after single subcutaneous KA (8 mg/kg) injection. The activity of Na+, K+-ATPase is also determined in rats pretreated with LTG (30 mg/kg) two hours before KA application. Hippocampal c-Jun and JNK induction were determined two hours and five days after KA treatment and also in LTG- pretreated rats. Na+, K+-ATPase activity was significantly inhibited the third and fifth day after KA application. C-Jun and JNK induction were observed two hours and five days after KA treatment. In the group of LTG- pretreated rats Na+, K+-ATPase inhibition, c-Jun and JNK induction were detected the fifth day after KA treatment. The inhibition of Na+, K+-ATPase observed the fifth day after KA administration was significantly less pronounced in the LTG- pretreated rats. It may be concluded that LTG has a partialy protective effect in KA-treated rats.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA