Naslov
Macrolide anti-inflammatory activity in lipopolysaccharide (LPS) induced inflammation models

Autori
Ivetić Tkalčević, Vanesa ; Bošnjak, Berislav ; Ferenčić, Željko ; Bosnar, Martina ; Marjanović, Nikola ; Šitum, Kristina ; Čulić, Ognjen ; Glojnarić, Ines ; Parnham, Michael J ; Eraković, Vesna ; Hrvačić, Boška

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts of the 2005 Annual Meeting of the Croatian Immunological Society / - , 2005

Skup
Annual Meeting of the Croatian Immunological Society

Mjesto i datum
Božava, Hrvatska, 29.09.2005. - 02.10.2005

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
azithromycin; clarithromycin; erythromycin; LPS; TNFa

Sažetak
Macrolides, apart from their antibacterial activity, suppress proinflammatory cytokine production and migration of inflammatory cells. Therefore we tested antiinflammatory activity of erythromycin (ERY), clarithromycin (CLA) and azithromycin (AZI) on LPS induced plasma tumor necrosis factor alpha (TNFa) production and lung neutrophilia. CLA significantly reduced TNFa concentration in plasma as well as total cell number, percentage of neutrophils and TNFa concentration in bronchoalveolar lavage fluid (BALF) and inflammatory cell infiltration into lung tissue. ERY exhibited an effect similar to CLA, while AZI markedly, although not significantly, decreased total cell number in BALF. Our results suggest that macrolides could differ in their acute antiinflammatory activity.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Veterinarska medicina

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