Pregled bibliografske jedinice broj: 474342
Chemotactic and protease-inhibiting activities of antibiotic peptide precursors
Chemotactic and protease-inhibiting activities of antibiotic peptide precursors // FEBS letters, 317 (1993), 3; 255-258 doi:10.1016/0014-5793(93)81287-A (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 474342 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Chemotactic and protease-inhibiting activities of antibiotic peptide precursors
Autori
Verbanac, Donatella ; Zanetti, Margherita ; Romeo, Domenico
Izvornik
FEBS letters (0014-5793) 317
(1993), 3;
255-258
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
antiobiotic peptides ; cathepsin L ; chemotaxis ; neutrophils. enzyme inhibition
Sažetak
We have recently shown that two antimicrobial peptides (Bac5 and Bac7) and/or their immature forms (proBac5 and proBac7) can be released extracellularly from activated neutrophils. In the present study we have investigated the biological activities of the immature forms, which do not exhibit antimicrobial effects. We show that proBac7 is a monocyte-selective chemoattractant, potentially contributing to the recruitment of these cells to infection sites, whereas proBac5 efficiently inhibits the in vitro activity of cathepsin L, a cysteine proteinase thought to contribute to tissue injury in inflammation.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
