Naslov
Concentration of C-reactive protein, magnesium and calcium in children with acute bronchoconstriction before and after thrapy with salbutamol

Autori
Dodig, Slavica ; Čepelak, Ivana ; Raos, Miljenko ; Zrinski Topić, Renata ; Živčić Jadranka ; Pavić, Ivan

Izvornik
Biochemia medica (1330-0962) 20 (2010), 2; 242-248

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
asthma; bronchocon striction; calcium; child; C-reactiveprotein; magnesium
(asthma; bronchoconstriction; calcium; child; C-reactiveprotein; magnesium)

Sažetak
In childhood, bronchoobstruction is mostly caused by respiratory viral infections. The aim of this study was to find out possible changes in serum concentration of magnesium and calcium (participants in bronchoconstriction), and concentration of C-reactive protein (marker of inflammation) in children with moderate and severe bronchoconstriction, caused by viral respiratory infections. The study included 32 children with acute bronchoconstriction caused by a viral respiratory infection. Inhalation of salbutamol was administered according to the severity of bronchoconstriction. Blood sampling was done on admission and the third day of salbutamol administration. Therapy with salbutamol led to a relief of dyspnea within 36 hours, and symptoms of viral infection have relieved. During follow-up period, magnesium was higher in children with moderate (but not in severe) bronchoconstriction than in healthy children, with consequently higher magnesium to calcium ratio. C-reactive protein decreased spontaneously by gradual disappearance of signs and symptoms of viral infection. Determination of serum magnesium and calcium concentrations and determination of their ratio are not sufficient enough to follow-up on effects of therapy. Additional studies of ionized forms of magnesium and calcium, their intracellular content, as well as concentration in exhaled breath condensate are needed.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija

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