Naslov
Enantioselective enzymatic esterification of lactic acid in ionic liquid

Autori
Nemeth, Gergely ; Nemestothy, Nandor ; FIndrik, Zvjezdana ; Gubicza, Laszlo

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Proceedings 37th International Conference of Chemical Engineering / Markoš, J. - , 2010, 1225-1230

ISBN
978-80-227-3290-1

Skup
37th International Conference of Chemical Engineering

Mjesto i datum
Tatranské Matliare, Slovačka, 24.05.2010. - 28.05.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
ionic liquid; enantioselectivity; lipase; esterification

Sažetak
Ionic liquids constitute of the hottest areas in chemistry these days. They are molten salts at room temperature with a melting point below 100 °C, which can be achieved by incorporating a bulky asymmetric cation into the structure together with a weakly-coordinating anion. Their unique, highly solvating features provide an attractive medium for various types of chemical processes, e.g. biocatalytic processes. Practically, they have no vapour pressure, which is a great advantage against conventional solvents. When a certain application requires a new solvent, ILs can be made task specific for it by a judicious variation in the lenght and branching of the alkyl chain and the anionic precursor. This is the reason why they are designated as tailor-made molecules. It is not negligible that the structure affects the environmentally features like biodegradability or toxicity. In the past few years several experiments were carried out in our institute to investigate the esterification of lactic acid (2-hydroxypropionic acid). At low water content lactic acid has an interesting feature. In that case it undergoes self esterification producing its open chain dimer, lactoyllactic acid, and other oligomers. Therefore investigating the water content during the reaction is essential, not only for the lactic acid oligomerization but for the enzymatic acitivity. The enzymatic esterification of racemic lactic acid with different alcohols was carried out in the presence of Cyphos type ionic liquids. Several lipase enzymes were used as catalysts for the enantioselective reactions. The reaction mixture contained lactic acid and alcohol, in an amount of 10 mmol and 120 mmol, respectively, additionally proper amount of ionic liquid and enzyme. Each enzyme investigated showed reasonable catalytic activity, their enantioselectivity could be effectively influenced by changing reaction parameters.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija

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