Naslov
Development and application of antimony film electrode in pharmaceutical analysis

Autori
Nigovic, Biljana ; Hocevar, Samo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts / Branka Zorc - Zagreb : Hrvatsko farmaceutsko društvo, 2010, 112-112

ISBN
978-953-96847-8-3

Skup
4. hrvatski kongres farmacije s međunarodnim sudjelovanjem

Mjesto i datum
Opatija, Hrvatska, 27.05.2010. - 30.05.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Voltammetry; Electrochemical sensor; Antimony film electrode; Pantoprazole

Sažetak
Electrochemical detection has been widely used as a powerful tool in pharmaceutical analysis. Apart from its relatively simple and inexpensive instrumentation, electroanalysis also offers practically unlimited possibilities for new sensor platform designs, measuring in untreated samples, on-site testing and miniaturization of sensing elements. In a search for new electrochemical sensor, the antimony film electrode (SbFE) was developed as an attractive alternative to common electrode materials. The SbFE was prepared ex situ on the surface of a glassy carbon electrode. Electroanalytical performance and the application of the SbFE in the area of drug analysis were investigated. Pantoprazole contains a sulfoxide group which could be reduced in the negative potential window of the SbFE. Drug molecule exhibited well-developed cathodic peak current at -1.15 V. The current value was sensitive to the pH of solutions. Considering the drug stability in aqueous solution, the dependence of voltammetric response on the pH of the measurement solution and the active potential window of the SbFE, which also depends on the pH of the supporting electrolyte, a value of pH 5.0 was found to be the best suited for analytical purpose. A new and sensitive electroanalytical method for pantoprazole determination was developed and validated. Under the optimized experimental conditions, in the square-wave voltammetric operation mode the SbFE showed a linear response in the concentration range of 9 × 10-6 to 2 × 10-4 M. The practical use of novel electrochemical sensor was demonstrated via measuring the related pharmaceutical dosage forms. The electrode surface revealed auspiciously high stability and remarkable reproducibility in the rapid analysis of drug in real pharmaceutical samples.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

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