Pregled bibliografske jedinice broj: 471970
One-pot Biocatalytic Synthesis of (S)-4-Chloro-3-hydroxybutanoate and Methyl (S)-Cyano-3-hydroxybutanoate
One-pot Biocatalytic Synthesis of (S)-4-Chloro-3-hydroxybutanoate and Methyl (S)-Cyano-3-hydroxybutanoate // Practical Methods for Biocatalysis and BIotransformations / Whittall, John ; Sutton, Peter (ur.).
Weinheim: John Wiley & Sons, 2009. str. 199-202
CROSBI ID: 471970 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
One-pot Biocatalytic Synthesis of (S)-4-Chloro-3-hydroxybutanoate and Methyl (S)-Cyano-3-hydroxybutanoate
Autori
Majerić Elenkov, Maja ; Tang, Lixia ; Hauer, Bernhard ; Janssen, Dick B.
Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, ostalo
Knjiga
Practical Methods for Biocatalysis and BIotransformations
Urednik/ci
Whittall, John ; Sutton, Peter
Izdavač
John Wiley & Sons
Grad
Weinheim
Godina
2009
Raspon stranica
199-202
ISBN
978-0-470-51927-1
Ključne riječi
biocatalysis, halohydrin dehalogenase, epoxide
Sažetak
The kinetic resolution of methyl 4-chloro-3-hydroxybutanoate by enantioselective epoxide ring opening with cyanide and a mutant halohydrin dehalogenase1 afforded two versatile building blocks in highly enantioenriched form (>95 % ee) and in high yield (81 % total yield). The transformation of halohydrin to cyanohydrin proceeds via an epoxide intermediate that is transiently present in low amount during the reaction. This is an example of a sequential kinetic resolution in which two steps are catalysed by a single halohydrin dehalogenase.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
098-0982933-2908 - Kiralni građevni blokovi za biološki aktivne molekule. Sinteza i reaktivnost (Hameršak, Zdenko, MZOS ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
Profili:
Maja Majerić Elenkov
(autor)
