Naslov
Platinum(II) complexes of 8-quinolylmethylphosphonates : Synthesis, characterization and antitumor activity

Autori
Tušek-Božić, Ljerka ; Juribašić, Marina ; Scarcia, Vito ; Furlani, Ariella

Izvornik
Polyhedron (0277-5387) 29 (2010), 12; 2527-2536

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
platinum(II) complex ; quinolylmethylphosphonate complex ; spectroscopy ; thermal analysis ; antitumor activity

Sažetak
A series of novel platinum(II) complexes of diethyl (8─dqmp) and monoethyl (8─Hmqmp) ester of 8─quinolylmethylphosphonic acid has been prepared and studied. It was shown that molecular or ionic complexes could be isolated by reaction of these organophosphorus ligands with [PtX4]2─ (X=Cl, Br), depending on the acidity of the reaction solution. In the neutral medium diester formed dihalide adducts, trans─[Pt(8─dqmp)2X2] (1 and 2), with N─bonded ligand through the quinoline nitrogen. Under acidic conditions (pH<3) both ligands gave the quinolinium salt complexes [LH]2[PtX4] (3 and 4, L=8─dqmp ; 7 and 8, L=8─Hmqmp), with protonated quinoline ligand as cation and tetrahalidoplatinate complex as anion. By heating in methanol complexes 3 and 4 were converted into the corresponding dimeric hexahalidodiplatinum complexes, [8─Hdqmp]2[Pt2X6] (5 and 6). The chelate complex [Pt(8─mqmp)2] (9), with monoester ligand bonded through the quinoline nitrogen and the deprotonated phosphonic acid oxygen and forming two seven-membered {; ; ; ; N, O}; ; ; ; chelate rings, was obtained in neutral and basic media by reaction of platinum(II) halides either with sodium or hydrochloride salt of this monoester. The complexes were identified and characterized by elemental and thermogravimetric analyses, conductometric measurements, and by spectroscopic studies. In vitro antitumor activity of complexes was evaluated against the human epidermoid KB and murine leukemia L1210 cell lines. These results were compared with those obtained for the palladium(II) complexes of the same phosphonate ligands and with those of platinum(II) and palladium(II) complexes of diethyl and monoethyl 2─quinolylmethylphosphonate, in order to correlate the structural and biological properties of quinoline─based aminophosphonate compounds.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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