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Pregled bibliografske jedinice broj: 471910

Novel 8a-aza-8a-homoerythromycin—400-(3- substituted-amino)propionates with broad spectrum antibacterial activity

Hutinec, Antun; Ðerek, Marko; Lazarevski, Gorjana; Šunjić, Vitomir; Čipčić Paljetak, Hana; Alihodžoć, Sulejman; Eraković Haber, Vesna; Dumić, Miljenko; Maršić, Nataša; Mutak, Stjepan
Novel 8a-aza-8a-homoerythromycin—400-(3- substituted-amino)propionates with broad spectrum antibacterial activity // Bioorganic & medicinal chemistry letters, 20 (2010), 11; 3244-3249 doi:10.1016/j.bmcl.2010.04.062 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 471910 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Novel 8a-aza-8a-homoerythromycin—400-(3- substituted-amino)propionates with broad spectrum antibacterial activity

Autori
Hutinec, Antun ; Ðerek, Marko ; Lazarevski, Gorjana ; Šunjić, Vitomir ; Čipčić Paljetak, Hana ; Alihodžoć, Sulejman ; Eraković Haber, Vesna ; Dumić, Miljenko ; Maršić, Nataša ; Mutak, Stjepan

Izvornik
Bioorganic & medicinal chemistry letters (0960-894X) 20 (2010), 11; 3244-3249

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
macrolide; azalide; 8a-aza-8a-Homoerythromycin—400-(3-substituted-amino)propionates; antibacterial activity; rResistance

Sažetak
Fifteen-membered 8a-aza-8a-homoerythromycins derived from either erythromycin or clarithromycin have been acylated to form 400-O-propenoyl derivative. These functionalized analogues underwent Michael reaction with primary or secondary amines to afford novel 8a-aza-8a- homoerythromycin—400- (3-substituted- amino)propionates. This preparative sequence was adapted so that analogues could be made by parallel synthesis. Among them, 4-quinolone derivatives show particularly good antibacterial potency against macrolide resistant bacteria, comparable or better than azithromycin and telithromycin.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
006-0000000-3216 - Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvari (Zorc, Branka, MZOS ) ( CroRIS)

Ustanove:
Fidelta d.o.o.

Profili:

Avatar Url Hana Čipčić Paljetak (autor)

Avatar Url Nataša Maršić (autor)

Avatar Url Miljenko Dumić (autor)

Avatar Url Gorjana Lazarevski (autor)

Avatar Url Antun Hutinec (autor)

Avatar Url Vitomir Šunjić (autor)

Avatar Url Vesna Eraković Haber (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com www.sciencedirect.com dx.doi.org

Citiraj ovu publikaciju:

Hutinec, Antun; Ðerek, Marko; Lazarevski, Gorjana; Šunjić, Vitomir; Čipčić Paljetak, Hana; Alihodžoć, Sulejman; Eraković Haber, Vesna; Dumić, Miljenko; Maršić, Nataša; Mutak, Stjepan
Novel 8a-aza-8a-homoerythromycin—400-(3- substituted-amino)propionates with broad spectrum antibacterial activity // Bioorganic & medicinal chemistry letters, 20 (2010), 11; 3244-3249 doi:10.1016/j.bmcl.2010.04.062 (međunarodna recenzija, članak, znanstveni)
Hutinec, A., Ðerek, M., Lazarevski, G., Šunjić, V., Čipčić Paljetak, H., Alihodžoć, S., Eraković Haber, V., Dumić, M., Maršić, N. & Mutak, S. (2010) Novel 8a-aza-8a-homoerythromycin—400-(3- substituted-amino)propionates with broad spectrum antibacterial activity. Bioorganic & medicinal chemistry letters, 20 (11), 3244-3249 doi:10.1016/j.bmcl.2010.04.062.
@article{article, author = {Hutinec, Antun and \DHerek, Marko and Lazarevski, Gorjana and \v{S}unji\'{c}, Vitomir and \v{C}ip\v{c}i\'{c} Paljetak, Hana and Alihod\v{z}o\'{c}, Sulejman and Erakovi\'{c} Haber, Vesna and Dumi\'{c}, Miljenko and Mar\v{s}i\'{c}, Nata\v{s}a and Mutak, Stjepan}, year = {2010}, pages = {3244-3249}, DOI = {10.1016/j.bmcl.2010.04.062}, keywords = {macrolide, azalide, 8a-aza-8a-Homoerythromycin—400-(3-substituted-amino)propionates, antibacterial activity, rResistance}, journal = {Bioorganic and medicinal chemistry letters}, doi = {10.1016/j.bmcl.2010.04.062}, volume = {20}, number = {11}, issn = {0960-894X}, title = {Novel 8a-aza-8a-homoerythromycin—400-(3- substituted-amino)propionates with broad spectrum antibacterial activity}, keyword = {macrolide, azalide, 8a-aza-8a-Homoerythromycin—400-(3-substituted-amino)propionates, antibacterial activity, rResistance} }
@article{article, author = {Hutinec, Antun and \DHerek, Marko and Lazarevski, Gorjana and \v{S}unji\'{c}, Vitomir and \v{C}ip\v{c}i\'{c} Paljetak, Hana and Alihod\v{z}o\'{c}, Sulejman and Erakovi\'{c} Haber, Vesna and Dumi\'{c}, Miljenko and Mar\v{s}i\'{c}, Nata\v{s}a and Mutak, Stjepan}, year = {2010}, pages = {3244-3249}, DOI = {10.1016/j.bmcl.2010.04.062}, keywords = {macrolide, azalide, 8a-aza-8a-Homoerythromycin—400-(3-substituted-amino)propionates, antibacterial activity, rResistance}, journal = {Bioorganic and medicinal chemistry letters}, doi = {10.1016/j.bmcl.2010.04.062}, volume = {20}, number = {11}, issn = {0960-894X}, title = {Novel 8a-aza-8a-homoerythromycin—400-(3- substituted-amino)propionates with broad spectrum antibacterial activity}, keyword = {macrolide, azalide, 8a-aza-8a-Homoerythromycin—400-(3-substituted-amino)propionates, antibacterial activity, rResistance} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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