Naslov
Drugs affecting GABA-ergic transmission and hypothalamic-pituitary-adrenal (HPA) axis

Autori
Pivac, Nela ; Peričić, Danka ; Geber, Juraj ; Bjegović, Milica ; Rešetić, Josip

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Pharmacological communications: Proceedings of the First Croatian Congress of Pharmacology / Bulat, Marin et al. - Zagreb, 1993, 125-127

ISBN
953-96081-0-4

Skup
First Croatian Congress of Pharmacology

Mjesto i datum
Zagreb, Hrvatska, 06.10.1993. - 08.10.1993

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
GABA; Diazepam; Picrotoxin; HPA axis; ACTH; Corticosterone; Rats

Sažetak
The function of gamma-aminobutyric acid (GABA, the major inhibitory neurotransmitter in the central nervous system) in the control of the hypothalamic-pituitary-adrenal (HPA) axis is not completely understood. With aim to elucidate this problem, we studied the effects of several drugs affecting GABAergic transmission on the adrenocorticotropic hormone (ACTH) and corticosterone (CS) secretion in rats. Intracerebroventricular (i.c.v.) administration of GABA decreased plasma ACTH and CS levels in female rats. Intraperitoneal (i.p.) administration of a low dose (1 mg/kg) of diazepam, a drug which facilitates the action of GABA at GABAA receptors, also decreased, while the same dose of picrotoxin, a non-competitive antagonist of GABA, increased plasma CS and ACTH levels. The results suggest that GABA exerts an inhibitory control over the HPA axis activity.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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