Pregled bibliografske jedinice broj: 470969
Effects of dihydroergosine and imipramine on 5-HT2 receptors in the rat brain
Effects of dihydroergosine and imipramine on 5-HT2 receptors in the rat brain // Iugoslavica physiologica et pharmacologica acta, 25 (1989), S7; 103-104 (podatak o recenziji nije dostupan, kratko priopcenje, znanstveni)
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Naslov
Effects of dihydroergosine and imipramine on 5-HT2 receptors in the rat brain
Autori
Muck-Šeler, Dorotea ; Peričić, Danka
Izvornik
Iugoslavica physiologica et pharmacologica acta (0021-3225) 25
(1989), S7;
103-104
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni
Ključne riječi
dihydroergosine ; iImipramine ; 5-HT2 receptors ; rat frontal cortex ; head twitch behaviour
Sažetak
The effects of a single i.p. injection of imipramine (30 mg/kg) and the potential antidepressant dihydroergosine (DHESN, 50 mg/kg) on in vitro properties of 5-HT2 receptors from the rat frontal cortex and on 5-HT2-mediated head twitch behaviour, produced in rats by i.p. administration of pargyline and 5-HTP, were studied. Eighty min after administration both drugs inhibited the binding of 3H-ketanserin, which labels 5-HT2 receptors, and reduced the number of head-twitches. The results suggest that the changes in the 5-HT2 binding properties may follow the acute and not only chronic treatment with antidepressants.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Ustanove:
Institut "Ruđer Bošković", Zagreb
