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Pregled bibliografske jedinice broj: 470227

New loci associated with kidney function and chronic kidney disease

Köttgen, A.; Pattaro, C.; Böger, C.A.; Fuchsberger, C.; Olden, M.; Glazer, N.L.; Parsa, A.; Gao, X.; Yang, Q.; Smith, A.V. et al.
New loci associated with kidney function and chronic kidney disease // Nature genetics, 42 (2010), 5; 376-384 doi:10.1038/ng.568 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 470227 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
New loci associated with kidney function and chronic kidney disease

Autori
Köttgen, A. ; Pattaro, C. ; Böger, C.A. ; Fuchsberger, C. ; Olden, M. ; Glazer, N.L. ; Parsa, A. ; Gao, X. ; Yang, Q. ; Smith, A.V. ; O'Connell, J.R. ; Li, M. ; Schmidt, H. ; Tanaka, T. ; Isaacs, A. ; Ketkar, S. ; Hwang, S.J. ; Johnson, A.D. ; Dehghan, A. ; Teumer, A. ; Paré, G. ; Atkinson, E.J. ; Zeller, T. ; Lohman, K. ; Cornelis, M.C. ; Probst-Hensch, N.M, ; Kronenberg, F. ; Tönjes, A. ; Hayward, C. ; Aspelund, T. ; Eiriksdottir, G. ; Launer, L.J. ; Harris, T.B. ; Rampersaud, E. ; Mitchell, B.D. ; Arking, D.E. ; Boerwinkle, E. ; Struchalin, M. ; Cavalieri, M. ; Singleton, A. ; Giallauria, F. ; Metter, J. ; de Boer, I.H. ; Haritunians, T. ; Lumley, T. ; Siscovick, D. ; Psaty, B.M. ; Zillikens, M.C. ; Oostra, B.A. ; Feitosa, M. ; Province, M. ; de Andrade, M. ; Turner, S.T. ; Schillert, A. ; Ziegler, A. ; Wild, P.S. ; Schnabel, R.B. ; Wilde, S. ; Munzel, T.F. ; Leak, T.S. ; Illig, T. ; Klopp, N. ; Meisinger, C. ; Wichmann, H.E. ; Koenig, W. ; Zgaga, Lina ; Zemunik, Tatijana ; Kolčić, Ivana ; Minelli, C. ; Hu, F.B. ; Johansson, A. ; Igl, W. ; Zaboli, G. ; Wild, S.H. ; Wright, A.F. ; Campbell, H. ; Ellinghaus, D. ; Schreiber, S. ; Aulchenko, Y.S. ; Felix, J.F. ; Rivadeneira, F. ; Uitterlinden, A.G. ; Hofman, A. ; Imboden, M. ; Nitsch, D. ; Brandstätter, A. ; Kollerits, B. ; Kedenko, L. ; Mägi, R. ; Stumvoll, M. ; Kovacs, P. ; Boban, M. ; Campbell, S. ; Endlich, K. ; Völzke, H. ; Kroemer, H.K. ; Nauck, M. ; Völker, U. ; Polašek, Ozren ; Vitart, V. ; Badola, S. ; Parker, A.N. ; Ridker, P.M. ; Kardia, S.L. ; Blankenberg, S. ; Liu, Y. ; Curhan, G.C. ; Franke, A. ; Rochat, T. ; Paulweber, B. ; Prokopenko, I. ; Wang, W. ; Gudnason, V. ; Shuldiner, A.R. ; Coresh, J. ; Schmidt, R. ; Ferrucci, L. ; Shlipak, M.G. ; van Duijn, C.M. ; Borecki, I. ; Krämer, B.K. ; Rudan, Igor ; Gyllensten, U. ; Wilson, J.F. ; Witteman, J.C. ; Pramstaller, P.P. ; Rettig, R. ; Hastie, N. ; Chasman, D.I. ; Kao, W.H. ; Heid, I.M. ; Fox, C.S.

Izvornik
Nature genetics (1061-4036) 42 (2010), 5; 376-384

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chronic kidney disease; loci; SNP

Sažetak
Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta- analysis of genome-wide association data in 67, 093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m(2) ; n = 5, 807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22, 982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA

Projekti:
216-1080315-0293 - Genetska epidemiologija šećerne bolesti tip 1 u populaciji Hrvatske (Zemunik, Tatijana, MZOS ) ( CroRIS)
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Polašek, Ozren, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb,
Medicinski fakultet, Split

Profili:

Avatar Url Tatijana Zemunik (autor)

Avatar Url Lina Zgaga (autor)

Avatar Url Ozren Polašek (autor)

Avatar Url Igor Rudan (autor)

Avatar Url Ivana Kolčić (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

Köttgen, A.; Pattaro, C.; Böger, C.A.; Fuchsberger, C.; Olden, M.; Glazer, N.L.; Parsa, A.; Gao, X.; Yang, Q.; Smith, A.V. et al.
New loci associated with kidney function and chronic kidney disease // Nature genetics, 42 (2010), 5; 376-384 doi:10.1038/ng.568 (međunarodna recenzija, članak, znanstveni)
Köttgen, A., Pattaro, C., Böger, C., Fuchsberger, C., Olden, M., Glazer, N., Parsa, A., Gao, X., Yang, Q. & Smith, A. (2010) New loci associated with kidney function and chronic kidney disease. Nature genetics, 42 (5), 376-384 doi:10.1038/ng.568.
@article{article, author = {K\"{o}ttgen, A. and Pattaro, C. and B\"{o}ger, C.A. and Fuchsberger, C. and Olden, M. and Glazer, N.L. and Parsa, A. and Gao, X. and Yang, Q. and Smith, A.V. and O'Connell, J.R. and Li, M. and Schmidt, H. and Tanaka, T. and Isaacs, A. and Ketkar, S. and Hwang, S.J. and Johnson, A.D. and Dehghan, A. and Teumer, A. and Par\'{e}, G. and Atkinson, E.J. and Zeller, T. and Lohman, K. and Cornelis, M.C. and Kronenberg, F. and T\"{o}njes, A. and Hayward, C. and Aspelund, T. and Eiriksdottir, G. and Launer, L.J. and Harris, T.B. and Rampersaud, E. and Mitchell, B.D. and Arking, D.E. and Boerwinkle, E. and Struchalin, M. and Cavalieri, M. and Singleton, A. and Giallauria, F. and Metter, J. and de Boer, I.H. and Haritunians, T. and Lumley, T. and Siscovick, D. and Psaty, B.M. and Zillikens, M.C. and Oostra, B.A. and Feitosa, M. and Province, M. and de Andrade, M. and Turner, S.T. and Schillert, A. and Ziegler, A. and Wild, P.S. and Schnabel, R.B. and Wilde, S. and Munzel, T.F. and Leak, T.S. and Illig, T. and Klopp, N. and Meisinger, C. and Wichmann, H.E. and Koenig, W. and Zgaga, Lina and Zemunik, Tatijana and Kol\v{c}i\'{c}, Ivana and Minelli, C. and Hu, F.B. and Johansson, A. and Igl, W. and Zaboli, G. and Wild, S.H. and Wright, A.F. and Campbell, H. and Ellinghaus, D. and Schreiber, S. and Aulchenko, Y.S. and Felix, J.F. and Rivadeneira, F. and Uitterlinden, A.G. and Hofman, A. and Imboden, M. and Nitsch, D. and Brandst\"{a}tter, A. and Kollerits, B. and Kedenko, L. and M\"{a}gi, R. and Stumvoll, M. and Kovacs, P. and Boban, M. and Campbell, S. and Endlich, K. and V\"{o}lzke, H. and Kroemer, H.K. and Nauck, M. and V\"{o}lker, U. and Pola\v{s}ek, Ozren and Vitart, V. and Badola, S. and Parker, A.N. and Ridker, P.M. and Kardia, S.L. and Blankenberg, S. and Liu, Y. and Curhan, G.C. and Franke, A. and Rochat, T. and Paulweber, B. and Prokopenko, I. and Wang, W. and Gudnason, V. and Shuldiner, A.R. and Coresh, J. and Schmidt, R. and Ferrucci, L. and Shlipak, M.G. and van Duijn, C.M. and Borecki, I. and Kr\"{a}mer, B.K. and Rudan, Igor and Gyllensten, U. and Wilson, J.F. and Witteman, J.C. and Pramstaller, P.P. and Rettig, R. and Hastie, N. and Chasman, D.I. and Kao, W.H. and Heid, I.M. and Fox, C.S.}, year = {2010}, pages = {376-384}, DOI = {10.1038/ng.568}, keywords = {chronic kidney disease, loci, SNP}, journal = {Nature genetics}, doi = {10.1038/ng.568}, volume = {42}, number = {5}, issn = {1061-4036}, title = {New loci associated with kidney function and chronic kidney disease}, keyword = {chronic kidney disease, loci, SNP} }
@article{article, author = {K\"{o}ttgen, A. and Pattaro, C. and B\"{o}ger, C.A. and Fuchsberger, C. and Olden, M. and Glazer, N.L. and Parsa, A. and Gao, X. and Yang, Q. and Smith, A.V. and O'Connell, J.R. and Li, M. and Schmidt, H. and Tanaka, T. and Isaacs, A. and Ketkar, S. and Hwang, S.J. and Johnson, A.D. and Dehghan, A. and Teumer, A. and Par\'{e}, G. and Atkinson, E.J. and Zeller, T. and Lohman, K. and Cornelis, M.C. and Kronenberg, F. and T\"{o}njes, A. and Hayward, C. and Aspelund, T. and Eiriksdottir, G. and Launer, L.J. and Harris, T.B. and Rampersaud, E. and Mitchell, B.D. and Arking, D.E. and Boerwinkle, E. and Struchalin, M. and Cavalieri, M. and Singleton, A. and Giallauria, F. and Metter, J. and de Boer, I.H. and Haritunians, T. and Lumley, T. and Siscovick, D. and Psaty, B.M. and Zillikens, M.C. and Oostra, B.A. and Feitosa, M. and Province, M. and de Andrade, M. and Turner, S.T. and Schillert, A. and Ziegler, A. and Wild, P.S. and Schnabel, R.B. and Wilde, S. and Munzel, T.F. and Leak, T.S. and Illig, T. and Klopp, N. and Meisinger, C. and Wichmann, H.E. and Koenig, W. and Zgaga, Lina and Zemunik, Tatijana and Kol\v{c}i\'{c}, Ivana and Minelli, C. and Hu, F.B. and Johansson, A. and Igl, W. and Zaboli, G. and Wild, S.H. and Wright, A.F. and Campbell, H. and Ellinghaus, D. and Schreiber, S. and Aulchenko, Y.S. and Felix, J.F. and Rivadeneira, F. and Uitterlinden, A.G. and Hofman, A. and Imboden, M. and Nitsch, D. and Brandst\"{a}tter, A. and Kollerits, B. and Kedenko, L. and M\"{a}gi, R. and Stumvoll, M. and Kovacs, P. and Boban, M. and Campbell, S. and Endlich, K. and V\"{o}lzke, H. and Kroemer, H.K. and Nauck, M. and V\"{o}lker, U. and Pola\v{s}ek, Ozren and Vitart, V. and Badola, S. and Parker, A.N. and Ridker, P.M. and Kardia, S.L. and Blankenberg, S. and Liu, Y. and Curhan, G.C. and Franke, A. and Rochat, T. and Paulweber, B. and Prokopenko, I. and Wang, W. and Gudnason, V. and Shuldiner, A.R. and Coresh, J. and Schmidt, R. and Ferrucci, L. and Shlipak, M.G. and van Duijn, C.M. and Borecki, I. and Kr\"{a}mer, B.K. and Rudan, Igor and Gyllensten, U. and Wilson, J.F. and Witteman, J.C. and Pramstaller, P.P. and Rettig, R. and Hastie, N. and Chasman, D.I. and Kao, W.H. and Heid, I.M. and Fox, C.S.}, year = {2010}, pages = {376-384}, DOI = {10.1038/ng.568}, keywords = {chronic kidney disease, loci, SNP}, journal = {Nature genetics}, doi = {10.1038/ng.568}, volume = {42}, number = {5}, issn = {1061-4036}, title = {New loci associated with kidney function and chronic kidney disease}, keyword = {chronic kidney disease, loci, SNP} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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