Pregled bibliografske jedinice broj: 469906
CYCLODEXTRIN ENHANCED TRICLOSAN RELEASE FROM MUCOADHESIVE, IN SITU CROSS-LINKED BUCCAL PATCHES
CYCLODEXTRIN ENHANCED TRICLOSAN RELEASE FROM MUCOADHESIVE, IN SITU CROSS-LINKED BUCCAL PATCHES // Collection of abstracts presented at the 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology at the Mediterranean Conference Centre in Valletta, Malta, from 8th March to 11th March 2010 / Siepmann, Juergen (ur.).
Valletta, 2010. str. 3-4 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 469906 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
CYCLODEXTRIN ENHANCED TRICLOSAN RELEASE FROM MUCOADHESIVE, IN SITU CROSS-LINKED BUCCAL PATCHES
Autori
Jug, Mario ; Landi, Elisa ; Maestrelli, Francesca ; Mura, Paola
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Collection of abstracts presented at the 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology at the Mediterranean Conference Centre in Valletta, Malta, from 8th March to 11th March 2010
/ Siepmann, Juergen - Valletta, 2010, 3-4
Skup
7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
Mjesto i datum
Valletta, Malta, 08.03.2010. - 11.03.2010
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Buccal delivery; mucoadhesive patches; chitosan; cyclodextrin; triclosan
Sažetak
The efficacy of conventional dosage forms in treatment of oral and dental diseases caused by microorganisms, such as dental caries and gingivitis, is often reduced by limited retention of the applied formulations within the oral cavity. The application of mucoadhesive dosage forms may be a suitable strategy to overcome this obstacle. With this aim we have developed and characterized novel in situ cross-linking mucoadhesive buccal patches, based on the combination of amidated pectin (AMP) and Carbopol (CAR). Furthermore, to obtain an adequate release profile of triclosan (TR), a broad spectrum antimicrobial agent with low aqueous solubility (10 microg/mL), we have utilized cyclodextrins, cyclic oligosaccharides which are able to modify undesirable biopharmaceutical properties of drugs by inclusion complex formation. The results have confirmed the in situ crosslinking between polymeric components of the formulation, resulting in formation of mucoadhesive matrix. Cyclodextrin based formulation showed superior in vitro performance in comparison to cyclodextrin free formulation, confirming the utility of such approach. The mechanism by wich cyclodextrin modulate the performance of was investigated in depth.
Izvorni jezik
Engleski
Znanstvena područja
Farmacija
