Pregled bibliografske jedinice broj: 469833
MUCOADHESIVE CHITOSAN FILMS WITH CYCLODEXTRINS AS A NOVEL BUCCAL DELIVERY SYSTEM FOR TRICLOSAN
MUCOADHESIVE CHITOSAN FILMS WITH CYCLODEXTRINS AS A NOVEL BUCCAL DELIVERY SYSTEM FOR TRICLOSAN // Collection of abstracts presented at the 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology at the Mediterranean Conference Centre in Valletta, Malta, from 8th March to 11th March 2010 / Siepmann, Juergen (ur.).
Valletta, 2010. str. 1-2 (poster, međunarodna recenzija, sažetak, znanstveni)
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Naslov
MUCOADHESIVE CHITOSAN FILMS WITH CYCLODEXTRINS AS A NOVEL BUCCAL DELIVERY SYSTEM FOR TRICLOSAN
(MUCOADHESIVE CHITOSAN FILMS WITH CYCLODEXTRINS AS A NOVEL BUCCAL DELIVERY SYSTEM FOR TRI)
Autori
Jug, Mario ; Mura, Paola ; Maestrelli, Francesca ; Cirri, Marzia
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Collection of abstracts presented at the 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology at the Mediterranean Conference Centre in Valletta, Malta, from 8th March to 11th March 2010
/ Siepmann, Juergen - Valletta, 2010, 1-2
Skup
7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
Mjesto i datum
Valletta, Malta, 08.03.2010. - 11.03.2010
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Buccal delivery; mucoadhesive films; chitosan; cyclodextrin; triclosan
Sažetak
Chitosan (CH) based mucoadhesive films may be suitable formulations to obtain buccal delivery of triclosan (TR). A broad antimicrobial spectrum of action and low systemic absorption makes TR a drug of choice for the local treatment of diseases of oral cavity such as plaque, carries and gingivitis. TR is practically insoluble in water, therefore its release from buccal formulations may be severely limited, leading to lack of the drug therapeutic effect. To overcome this obstacle, suitable carriers such as cyclodextrins should be used. These cyclic oligosaccharides, consisting of 6, 7 or 8 a-1, 4 linked glucopiranose, units are biocompatible molecules capable to change the undesirable biopharmaceutical properties of the drugs by inclusion complex formation. The results of presented research have demonstrateh the superior performance of cyclodextrin based chitosan films in comparison to formulation where drug alone was loaded. The paramethers influencing the important biopharmaceutical parameters of the formulation were inwestigated in depth.
Izvorni jezik
Engleski
Znanstvena područja
Farmacija
