Naslov
Imipramine and dihydroergosine-induced dual changes of 5-HT receptor subtypes

Autori
Peričić, Danka ; Muck-Šeler, Dorotea

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Psychopharmacology Vol. 96 Suppl. / Book of Abstracts / - , 1988, 198-198

Skup
XVIth C.I.N.P. Congress

Mjesto i datum
München, Njemačka, 15.08.1988. - 19.08.1988

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Imipramine; Dihydroergosine; 5-HT syndrome; Head-twitch behaviour; 5-HT1 and 5-HT2 receptors

Sažetak
The mechanisms by which imipramine and dihydroergosine stimulate the 5-HT syndrome in rats and inhibit the head-twitch response in rats and mice were studied. Imipramine- and dihydroergosine-induced stimulation of the 5-HT syndrome was inhibited stereoselectively by propranolol, a high affinity ligand for 5-HT1 receptor sites, but not by ritanserin, a specific 5-HT2 receptor antagonist. (-)-Propranolol potentiated the inhibitory effect of imipramine, but not of dihydroergosine on the head-twitch response, while ritanserin was without effect. Neither imipramine nor dihydroergosine were able to stimulate the 5-HT syndrome in the animals pretreated with p-chlorophenylalanine. In in vitro experiments dihydroergosine expressed approximately twenty-fold higher affinity for 3H-ketanserin binding sites than imipramine. The results suggest that imipramine and dihydroergosine possess two components--one stimulating the 5-HT syndrome in rats by a presynaptic, presumably 5-HT1A-mediated mechanism, and the other inhibiting 5-HT2 binding sites.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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