Naslov
The anticonvulsant action of GABA system is sex dependent

Autori
Manev, Hari ; Peričić, Danka ; Geber, Juraj ; Anić-Stojiljković, Suzana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Psychopharmacology Vol. 89 Suppl. / - , 1986, S22-S22

Skup
Inaugural Meeting of the European Behavioural Pharmacology Society

Mjesto i datum
Antwerpen, Belgija, 02.07.1986. - 07.07.1986

Vrsta sudjelovanja
Ostalo

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
GABA-blocking agents; mice; rats; convulsions; spinal motoneurons discharge

Sažetak
The administration of the GABA-blocking agents picrotoxin and bicuculline to adult CBA/HZgr mice resulted in the appearance of convulsions, the occurrence and/or lethality of which was greater in males than in females. The latency of picrotoxin-induced convulsions was also shorter in male mice. Strychnine, a drug which induces convulsions by blocking glycine receptors was equally effective in producing convulsions in both male and female adult mice. Unlike adult mice, young (20 days old) or old (2 years old) mice fail to display sex differences following the picrotoxin administration. Rats responded oppositely than mice, i.e., following administration of GABA-related convulsants, females were more sensitive than males.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA