Naslov
Regional differences in NaCl-induced increase of the potency of bicuculline to displace 3H-muscimol binding

Autori
Bujas, Maja ; Tvrdeić, Ante ; Peričić, Danka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Pharmacological Research Vol. 31 Suppl. 1 / - , 1995, 319-319

Skup
First European Congress of Pharmacology

Mjesto i datum
Milano, Italija, 16.06.1995. - 19.06.1995

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
3H-Muscimol binding; Bicuculline; NaCl; Cortex; Cerebellum

Sažetak
It has been shown that the potency of bicuculline to displace [3H]muscimol binding to crude brain membranes can be enhanced markedly by different anions. This study shows that although bicuculline alone was a more potent displacer of [3H]muscimol binding in cortical than in cerebellar membranes, the NaCl (250 mM)-induced leftward shift of the bicuculline inhibition curve of [3H]muscimol binding was considerably higher in cerebellum than in cortex. The some concentration of NaCl failed to affect either the affinity or the density of cortical and cerebellar [3H]muscimol binding sites. The results suggest that sodium chloride is able to reveal regional differences in bicuculline potency.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA